# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5157564 | T | Cytotoxicity against human HEp-2 cells assessed as loss of cell integrity by measuring cytosolic LDH release at 25 to 100 uM measured after 30 mins by LDH assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA5157565 | B | Inhibition of recombinant Chlamydia trachomatis HtrA serine protease using MeOCoum-ENLHLPLPI1F-D as substrate measured after 30 mins | Chlamydia trachomatis | 15 | single protein format | Scientific Literature | ||
3. | ALA5157566 | B | Potency index, ratio of JO146 IC50 to test compound IC50 for inhibition of recombinant Chlamydia trachomatis HtrA serine protease using MeOCoum-ENLHLPLPI1F-D as substrate measured after 30 mins | Chlamydia trachomatis | 14 | single protein format | Scientific Literature | ||
4. | ALA5157567 | B | Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins | Homo sapiens | 18 | single protein format | Scientific Literature | ||
5. | ALA5157568 | B | Potency index, ratio of JO146 IC50 to test compound IC50 for inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins | Homo sapiens | 17 | single protein format | Scientific Literature | ||
6. | ALA5157569 | F | Antibacterial activity against Chlamydia trachomatis D/UW-3/Cx infected in human HEp-2 cells assessed as log reduction in chlamydial inclusion forming units at 25 uM administered at 16 hrs post infection and measured 44 hrs post infection | Chlamydia trachomatis | 1 | organism-based format | Scientific Literature | ||
7. | ALA5157570 | F | Antibacterial activity against Chlamydia trachomatis D/UW-3/Cx infected in human HEp-2 cells assessed as reduction in bacterial titer below threshold at 50 uM administered at 16 hrs post infection and measured 44 hrs post infection | Chlamydia trachomatis | 4 | organism-based format | Scientific Literature | ||
8. | ALA5157571 | F | Antibacterial activity against Chlamydia pecorum MC/MarsBar infected in human HEp-2 cells assessed as reduction in bacterial titre at 25 uM administered at 16 hrs post infection and measured 44 hrs post infection | Chlamydia pecorum | 8 | organism-based format | Scientific Literature | ||
9. | ALA5157572 | T | Cytotoxicity against human HEp-2 cells assessed as cell viability at 25 to 100 uM measured after 24 hrs by MTS assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |