| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5151004 | B | Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 2. | ALA5151011 | A | Protein binding in mouse plasma assessed as unbound fraction | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 3. | ALA5151013 | A | Brain to plasma ratio in mouse at 30 mg/kg, po bid for 30 days by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA5151015 | A | Half life in mouse at 1 mg/kg,iv for 30 days by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA5151016 | A | Oral bioavailability in mouse at 30 mg/kg, bid for 30 days by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA5151017 | A | Cmax in mouse at 10 mg/kg, po bid for 30 days by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5151018 | A | AUC (0-infinity) in mouse at 10 mg/kg, po bid for 30 days by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5166899 | A | Apparent permeability of the compound across basolateral side to apical side in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5166900 | A | Apparent permeability of the compound across apical to basolateral side in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5166901 | B | Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant expressed in HEK293S cells using OPTS as substrate incubated for 40 mins by fluorescence based assay | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 11. | ALA5166902 | P | Octanol/buffer distribution coefficient, logD of compound at pH 7.4 by shake flask method based LC-UV analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA5166903 | P | Aqueous solubility of compound in PBS at pH 7.4 | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA5166904 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 7 | microsome format | Scientific Literature | ||
| 14. | ALA5166905 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 15. | ALA5166906 | A | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells | Canis lupus familiaris | 7 | cell-based format | Scientific Literature | ||
| 16. | ALA5166907 | A | Apparent permeability across basolateral to apical side in MDCK-MDR1 cells | Canis lupus familiaris | 7 | cell-based format | Scientific Literature | ||
| 17. | ALA5166908 | A | Efflux ratio of apparent permeability from apical to basolateral side over basolateral to apical side in MDCK-MDR1 cells | Canis lupus familiaris | 7 | cell-based format | Scientific Literature | ||
| 18. | ALA5166909 | A | Permeability coefficient in C57BL6 mouse assessed as brain to plasma ratio at 10 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA5166910 | B | Inhibition of full length recombinant human Notum expressed in HEK293S cells expressing TCF-LEF preincubated for 30 mins followed by Wnt-3A addition and measured after 1 hr by luminescence based microplate reader analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5166911 | A | Clearance in C57BL6 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature |
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