| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5162302 | B | Inhibition of wild type human GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 cells incubated for 30 mins in presence of ATP by HTRF analysis | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA5162303 | B | Inhibition of wild type human N-terminal GST tagged EGFR (669 to 1210 residues) expressed in Sf21 insect cells incubated for 30 mins in presence of ATP by HTRF analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA5162304 | B | Selectivity ratio of IC50 for wild type human N-terminal GST tagged EGFR (669 to 1210 residues) expressed in Sf21 insect cells to IC50 for wild type human GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 cells | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA5162305 | F | Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter-Glo assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 5. | ALA5162306 | F | Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter-Glo assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 6. | ALA5162307 | T | Toxicity in BALB/c nude mouse xenografted with human NCI-N87 cells assessed as mortality at 5 to 40 mg/kg, po administered once daily for 21 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5162308 | T | Toxicity in BALB/c nude mouse xenografted with human NCI-N87 cells assessed as reduction in body weight at 5 to 40 mg/kg, po administered once daily for 21 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5162309 | F | Antitumor activity against human NCI-N87 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition by measuring relative tumor growth at 20 mg/kg/day, po administered once daily for 21 days by caliper method relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5162310 | F | Antitumor activity against human NCI-N87 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition by measuring relative tumor growth at 10 mg/kg/day, po administered once daily for 21 days by caliper method relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5162311 | B | Potency index, ratio of test compound IC50 to neratinib IC50 for inhibition of wild type human GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 cells incubated for 30 mins in presence of ATP by HTRF analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 11. | ALA5162312 | B | Potency index, ratio of test compound IC50 to pyrotinib IC50 for inhibition of wild type human GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 cells incubated for 30 mins in presence of ATP by HTRF analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 12. | ALA5162313 | F | Antitumor activity against human NCI-N87 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition by measuring relative tumor growth at 5 mg/kg/day, po administered once daily for 21 days by caliper method relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5162314 | A | Metabolic stability in human liver microsomes assessed as half life at 1 uM preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 14. | ALA5162315 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 15. | ALA5162316 | A | Clearance in ICR mouse at 3 mg/kg, iv measured upto 1440 mins by LC/MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA5162317 | A | Clearance in Sprague-Dawley rat at 3 mg/kg, iv measured upto 1440 mins by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA5162318 | A | Clearance in cynomolgus monkey at 1 mg/kg, iv measured upto 1440 mins by LC/MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5162319 | A | Half life in ICR mouse at 3 mg/kg, iv measured upto 1440 mins by LC/MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA5162320 | A | Volume of distribution at steady state in ICR mouse at 3 mg/kg, iv measured upto 1440 mins by LC/MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA5162321 | A | Cmax in ICR mouse at 10 mg/kg, po measured upto 1440 mins by LC/MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature |
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