# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5165540 | Binding | Inhibition of MKK3-p38-elF4E signaling pathway in mouse RAW264.7 cells assessed as inhibition of LPS-induced TAK1 phosphorylation upto 30 uM | Mus musculus | 1 | ALA5154881 | cell-based format | Scientific Literature | |
2. | ALA5165541 | Functional | Antiinflammatory activity against DSS-induced C57BL/6 mouse model of acute ulcerative colitis assessed as reduction in serum IL-6 levels administered intragastrically via gavage measured after 7 days by ELISA | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
3. | ALA5165542 | Functional | Inhibition of LPS-induced TNFalpha production in mouse RAW264.7 cells at 50 uM preincubated for 2 hrs followed by LPS treatment for 24 hrs by RT-qPCR analysis relative to control | Mus musculus | 21 | ALA5154881 | cell-based format | Scientific Literature | |
4. | ALA5165543 | Functional | Inhibition of LPS-induced TNFalpha production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS treatment for 24 hrs by RT-qPCR analysis | Mus musculus | 12 | ALA5154881 | cell-based format | Scientific Literature | |
5. | ALA5165544 | ADME | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 1 | ALA5154881 | microsome format | Scientific Literature | |
6. | ALA5165545 | ADME | Metabolic stability in dog liver microsomes assessed as intrinsic clearance at 5 mmol/L measured upto 60 mins in presence of NADPH by HPLC-MS analysis | Canis lupus familiaris | 1 | ALA5154881 | microsome format | Scientific Literature | |
7. | ALA5165546 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 5 mmol/L measured upto 60 mins in presence of NADPH by HPLC-MS analysis | Homo sapiens | 1 | ALA5154881 | microsome format | Scientific Literature | |
8. | ALA5165547 | Physicochemical | n-Octanol/water partition coefficient, logP of the compound incubated for 24 hrs by HPLC analysis | 1 | ALA5154881 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5165548 | ADME | Apparent permeability in dog MDCK-MDR1 cells transfected with human P-gp | Canis lupus familiaris | 1 | ALA5154881 | cell-based format | Scientific Literature | |
10. | ALA5165549 | ADME | Efflux ratio of apparent permeability in dog MDCK-MDR1 cells transfected with human P-gp | Canis lupus familiaris | 1 | ALA5154881 | cell-based format | Scientific Literature | |
11. | ALA5165550 | Toxicity | Inhibition of hERG | Homo sapiens | 1 | ALA5154881 | assay format | Scientific Literature | |
12. | ALA5165551 | Toxicity | Mutagenicity in Salmonella typhimurium by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA5154881 | assay format | Scientific Literature | |
13. | ALA5165552 | ADME | Tmax in 12 hr starved C57 mouse at 30 mg/kg, po measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
14. | ALA5165553 | ADME | AUC (0 to t) in 12 hr starved C57 mouse at 5 mg/kg, iv measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
15. | ALA5165554 | ADME | AUC (0 to infinity) in 12 hr starved C57 mouse at 5 mg/kg, iv measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
16. | ALA5165555 | ADME | MRT (0 to infinity) in 12 hr starved C57 mouse at 5 mg/kg, iv measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
17. | ALA5165556 | ADME | Cmax in 12 hr starved C57 mouse at 5 mg/kg, iv measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
18. | ALA5165557 | ADME | Half life in 12 hr starved C57 mouse at 5 mg/kg, iv measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
19. | ALA5165558 | ADME | Apparent volume of distribution in 12 hr starved C57 mouse at 5 mg/kg, iv measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature | |
20. | ALA5165559 | ADME | Cmax in 12 hr starved C57 mouse at 30 mg/kg, po measured for 0.083 to 24 hrs post-dose by LC-MS-MS analysis | Mus musculus | 1 | ALA5154881 | organism-based format | Scientific Literature |