# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5126113 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of CDK12 degradation incubated for 15 hrs by immunoblotting analysis | Homo sapiens | 8 | ALA5120962 | cell-based format | Scientific Literature | |
2. | ALA5126116 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of CDK12 degradation at 1 uM incubated for 15 hrs by immunoblotting analysis relative to control | Homo sapiens | 27 | ALA5120962 | cell-based format | Scientific Literature | |
3. | ALA5126117 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of CDK13 degradation at 1 uM incubated for 15 hrs by immunoblotting analysis relative to control | Homo sapiens | 27 | ALA5120962 | cell-based format | Scientific Literature | |
4. | ALA5126118 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of CDK13 degradation incubated for 15 hrs by immunoblotting analysis | Homo sapiens | 8 | ALA5120962 | cell-based format | Scientific Literature | |
5. | ALA5126151 | Functional | Invivo protac activity at CRBN/CDK12 in human MDA-MB-231 cells xenografted in CB17SCID mouse assessed as degradation of CDK12 in tumor at 50 mg/kg, iv measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5120962 | organism-based format | Scientific Literature | |
6. | ALA5126152 | Functional | Invivo protac activity at CRBN/CDK13 in human MDA-MB-231 cells xenografted in CB17SCID mouse assessed as degradation of CDK12 in tumor at 50 mg/kg, iv measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5120962 | organism-based format | Scientific Literature |