| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5159662 | F | Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay | Homo sapiens | 46 | cell-based format | Scientific Literature | ||
| 2. | ALA5159664 | F | Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA5159665 | F | Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA5159667 | F | Antagonist activity at GPR84 expressed in mouse bone marrow cells assessed as reduction in 6-OAU induced migration in neutrophils incubated for 90 mins by flow cytometry | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5159668 | F | Antagonist activity at GPR84 expressed in mouse bone marrow cells assessed as reduction in 6-OAU/3-OH-C12 induced migration in monocytes incubated for 90 mins by flow cytometry | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5159669 | A | Tmax in CD-1 mouse at 5 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 7. | ALA5159670 | A | Cmax in CD-1 mouse at 5 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 8. | ALA5159671 | A | MRT in CD-1 mouse at 2 mg/kg, iv administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA5159672 | A | AUC(0 to infinity) in CD-1 mouse at 5 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 10. | ALA5159673 | A | AUC(0 to infinity) in CD-1 mouse at 2 mg/kg, iv administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA5159674 | A | Half life in CD-1 mouse at 5 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA5159675 | A | Half life in CD-1 mouse at 2 mg/kg, iv administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA5159676 | A | Clearance in CD-1 mouse at 2 mg/kg, iv administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA5159677 | A | MRT in CD-1 mouse at 5 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 15. | ALA5159678 | A | Oral bioavailability in CD-1 mouse at 5 mg/kg administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 16. | ALA5159679 | A | Volume of distribution at steady state in CD-1 mouse at 2 mg/kg, iv administered as single dose measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA5159680 | A | Drug distribution in DSS-induced ulcerative colitis mouse jejunum at 5 mg/kg, po administered as single dose measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5159681 | A | Drug distribution in DSS-induced ulcerative colitis mouse colon at 5 mg/kg, po administered as single dose measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5159682 | F | Anti-colitis activity against DSS-induced ulcerative colitis mouse model assessed as attenuation of weight loss administered orally once daily for 7 consecutive days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5159683 | F | Anti-colitis activity against DSS-induced ulcerative colitis mouse model assessed as attenuation of stool thinning administered orally once daily for 7 consecutive days | Mus musculus | 1 | organism-based format | Scientific Literature |
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