| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5144565 | B | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by DTNB-reagent based Ellman's method | Electrophorus electricus | 26 | single protein format | Scientific Literature | ||
| 2. | ALA5144566 | B | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by DTNB-reagent based Ellman's method | Equus caballus | 26 | single protein format | Scientific Literature | ||
| 3. | ALA5144567 | B | Mixed type inhibition of equine serum BuChE assessed as decrease in Vmax with increase in Km at 0.5 to 2 uM using varying level of butyrylthiocholine iodide as substrate by Lineweaver-Burk plot double reciprocal analysis | Equus caballus | 1 | single protein format | Scientific Literature | ||
| 4. | ALA5144568 | B | Mixed type inhibition of equine serum BuChE assessed as inhibition constant using varying level of butyrylthiocholine iodide as substrate by Lineweaver-Burk plot double reciprocal analysis | Equus caballus | 1 | single protein format | Scientific Literature | ||
| 5. | ALA5144569 | F | Inhibition of NO production in LPS-induced mouse BV-2 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA | Mus musculus | 26 | cell-based format | Scientific Literature | ||
| 6. | ALA5144571 | F | Neuroprotective activity against H202-induced cell death in rat PC-12 cells assessed as cell viability at 5 uM pretreated for 3 hrs followed by H2O2 stimulation and measured after 24 hrs by MTT assay relative to control | Rattus norvegicus | 24 | cell-based format | Scientific Literature | ||
| 7. | ALA5144572 | F | Neuroprotective activity against H202-induced cell death in rat PC-12 cells assessed as cell viability at 20 uM pretreated for 3 hrs followed by H2O2 stimulation and measured after 24 hrs by MTT assay relative to control | Rattus norvegicus | 24 | cell-based format | Scientific Literature | ||
| 8. | ALA5144573 | T | Cytotoxicity against rat PC-12 cells assessed as cell viability at 25 uM incubated for 24 hrs by MTT assay relative to control | Rattus norvegicus | 24 | cell-based format | Scientific Literature | ||
| 9. | ALA5144574 | T | Cytotoxicity against rat PC-12 cells assessed as cell viability at 50 uM incubated for 24 hrs by MTT assay relative to control | Rattus norvegicus | 24 | cell-based format | Scientific Literature | ||
| 10. | ALA5144575 | B | Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregation at 100 uM measured after 48 hrs by thioflavin-T fluorescence method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA5144577 | B | Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregation at 100 uM measured after 48 hrs by transmission electron microscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA5144578 | F | Inhibition of LPS-induced IL-1beta secretion in mouse BV-2 cells preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5144579 | F | Inhibition of LPS-induced TNF-alpha secretion in mouse BV-2 cells preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5144580 | F | Downregulation of COX-2 protein expression in LPS-stimulated mouse BV-2 cells preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5144581 | F | Downregulation of iNOS protein expression in LPS-stimulated mouse BV-2 cells preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5144582 | B | Inhibition of IkappaB activation in LPS-stimulated mouse BV-2 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5144583 | B | Inhibition of IkappaB phosphorylation in LPS-stimulated mouse BV-2 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5144584 | B | Inhibition of p65 phosphorylation in LPS-stimulated mouse BV-2 cells at 1 to 10 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5144585 | B | Inhibition of NF-kappaB in LPS-stimulated mouse BV-2 cells assessed as reduction in translocation of p65 NF-kappaB from cytoplasm to nucleus at 1 to 10 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5144586 | F | Inhibition of H2O2-induced ROS production in rat PC-12 cells assessed as reduction in ROS accumulation at 1 to 50 uM pretreated for 6 hrs followed by H2O2 stimulation and measured after 18 hrs by DCFH-DA staining based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature |
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