| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5156553 | A | AUC (0 to infinity) in Sprague-Dawley rat at 25 mg/kg, po measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA5156554 | B | Inhibition of His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by HTRF assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 3. | ALA5156555 | B | Binding affinity to His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 4. | ALA5156556 | B | Binding affinity to His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by ITC analysis | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 5. | ALA5156557 | F | Antiproliferative activity against human LNCaP C4-2B cells assessed as inhibition of cell growth by Celltiter-Glo assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 6. | ALA5156559 | A | AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg, iv administered as single dose measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA5156562 | A | Cmax in Sprague-Dawley rat at 25 mg/kg, po measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA5156563 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, iv administered as single dose measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA5156565 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, iv administered as single dose measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA5156567 | A | Half life in Sprague-Dawley rat at 25 mg/kg, po measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA5156568 | A | Half life in Sprague-Dawley rat at 5 mg/kg, iv administered as single dose measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA5156569 | A | Oral bioavailability in Sprague-Dawley rat at 25 mg/kg measured up to 24 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA5156570 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM incubated for 45 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 14. | ALA5156571 | B | Binding affinity to His6-tagged human EP300 bromodomain (1040 to 1161 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 15. | ALA5156572 | B | Binding affinity to His6-tagged human PHIP bromodomain-2 (1302 to 1433 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 16. | ALA5156573 | B | Binding affinity to His6-tagged human CECR-2 bromodomain (425 to 538 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 17. | ALA5156574 | B | Binding affinity to His6-tagged human BAZ2B bromodomain (1858 to 1972 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 18. | ALA5156575 | B | Binding affinity to His6-tagged human PCAF bromodomain (715 to 831 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 19. | ALA5156576 | B | Binding affinity to His6-tagged human BRD4 bromodomain-1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 20. | ALA5156577 | B | Binding affinity to His6-tagged human BRD4 bromodomain-2 (332 to 460 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability by measuring change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 6 | assay format | Scientific Literature |
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