| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5165829 | B | Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 60 mins followed by substrate addition for 30 mins by microplate reader method | Homo sapiens | 19 | ALA5154884 | single protein format | Scientific Literature | |
| 2. | ALA5165830 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK4/Cyclin D3 expressed in Sf9 insect cells using 5-FAM-IPTSPITTTYFFFKKK as substrate preincubated for 10 mins followed by substrate addition and incubated for 3 hrs in presence of ATP by caliper mobility shift analysis | Homo sapiens | 19 | ALA5154884 | cell-based format | Scientific Literature | |
| 3. | ALA5165831 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5154884 | cell-based format | Scientific Literature | |
| 4. | ALA5165832 | F | Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5154884 | cell-based format | Scientific Literature | |
| 5. | ALA5165834 | F | Antiproliferative activity against mouse EMT6 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Mus musculus | 7 | ALA5154884 | cell-based format | Scientific Literature | |
| 6. | ALA5165836 | B | Inhibition of SHP2 PTP domain (unknown origin) using DiFMUP as substrate preincubated for 20 mins followed by substrate addition and measured for 2 hrs by fluorescence based analysis | Homo sapiens | 1 | ALA5154884 | single protein format | Scientific Literature | |
| 7. | ALA5165837 | B | Inhibition of SHP1 (unknown origin) using DiFMUP as substrate preincubated for 20 mins followed by substrate addition and measured for 2 hrs by fluorescence based analysis | Homo sapiens | 1 | ALA5154884 | single protein format | Scientific Literature | |
| 8. | ALA5165838 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK1/Cyclin B expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 9. | ALA5165839 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK2/Cyclin E2 expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 10. | ALA5165840 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK3/Cyclin E expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 11. | ALA5165841 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK4/Cyclin D3 expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 12. | ALA5165842 | B | Inhibition of recombinant full length N-terminal GST/His6-fusion tagged human CDK5/P25 expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 13. | ALA5165843 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK6/Cyclin D3 expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 14. | ALA5165844 | B | Inhibition of CDK7/Cyclin H (unknown origin) incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | protein complex format | Scientific Literature | |
| 15. | ALA5165845 | B | Inhibition of recombinant full length N-terminal GST/His6-fusion tagged human CDK9/Cyclin T1 expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 16. | ALA5165846 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK12/Cyclin K expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 17. | ALA5165847 | B | Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK13/Cyclin K expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay | Homo sapiens | 1 | ALA5154884 | cell-based format | Scientific Literature | |
| 18. | ALA5165848 | F | Induction of cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells in G0/G1 phase at 3 uM incubated for 48 hrs by RNase/propidium iodide staining based flow cytometry analysis (Rvb = 26.2%) | Homo sapiens | 3 | ALA5154884 | cell-based format | Scientific Literature | |
| 19. | ALA5165849 | F | Induction of cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells in S phase at 3 uM incubated for 48 hrs by RNase/propidium iodide staining based flow cytometry analysis (Rvb = 71.1%) | Homo sapiens | 3 | ALA5154884 | cell-based format | Scientific Literature | |
| 20. | ALA5165850 | F | Induction of cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells in G2/M phase at 3 uM incubated for 48 hrs by RNase/propidium iodide staining based flow cytometry analysis (Rvb = 2.7%) | Homo sapiens | 3 | ALA5154884 | cell-based format | Scientific Literature |
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