# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5144358 | B | Inhibition of human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21 (DE3) at 250 nM using KKISGRLSPIMTEQ as substrate incubated in presence of ATP relative to control | Homo sapiens | 27 | ALA5143522 | assay format | Scientific Literature | |
2. | ALA5144360 | B | Inhibition of human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21 (DE3) using KKISGRLSPIMTEQ as substrate incubated in presence of ATP | Homo sapiens | 8 | ALA5143522 | assay format | Scientific Literature | |
3. | ALA5144363 | B | Inhibition of CDK5/p25 (unknown origin) at 1 uM by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | protein complex format | Scientific Literature | |
4. | ALA5144364 | B | Inhibition of GST-tagged human recombinant CLK1 (129 to 484 residues) expressed in Escherichia coli at 1 uM using GRSRSRSRSRSRSRSR as substrate incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | assay format | Scientific Literature | |
5. | ALA5144365 | B | Inhibition of CSNK1D (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
6. | ALA5144367 | B | Inhibition of HIPK1 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay | Homo sapiens | 1 | ALA5143522 | single protein format | Scientific Literature | |
7. | ALA5144368 | B | Inhibition of NTRK2 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
8. | ALA5144369 | B | Inhibition of PIM1 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
9. | ALA5144370 | B | Inhibition of SRPK1 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
10. | ALA5144371 | B | Inhibition of DYRK2 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
11. | ALA5144373 | B | Inhibition of MLCK2 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay | Homo sapiens | 1 | ALA5143522 | single protein format | Scientific Literature | |
12. | ALA5144374 | B | Inhibition of STK17A (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
13. | ALA5144376 | B | Inhibition of GSG2 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay | Homo sapiens | 1 | ALA5143522 | single protein format | Scientific Literature | |
14. | ALA5144377 | B | Inhibition of GSK3beta (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control | Homo sapiens | 2 | ALA5143522 | single protein format | Scientific Literature | |
15. | ALA5144378 | B | Binding affinity to C-terminal HiBiT-tagged human DYRK1A (28 to 499 residues) stably expressed in HEK293 cells assessed as thermal stability by measuring increase in DYRK1A in soluble fraction at 10 to 30 uM incubated for 3.5 mins by ITDRF-CETSA analysis | Homo sapiens | 1 | ALA5143522 | cell-based format | Scientific Literature | |
16. | ALA5144379 | B | Inhibition of DYRK1A in human HeLa cells transiently expressing GFP-SF3B1 fusion protein assessed as reduction in SF3B1 phosphorylation incubated for 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5143522 | cell-based format | Scientific Literature | |
17. | ALA5144386 | A | Permeability of the compound in PBS/EtOH buffer (7:3) incubated for 16 hrs by PAMPA-BBB assay | 5 | ALA5143522 | assay format | Scientific Literature | ||
18. | ALA5144390 | B | Inhibition of human recombinant DYRK1B at 1 uM using KKISGRLSPIMTEQ as substrate incubated in presence of ATP | Homo sapiens | 1 | ALA5143522 | single protein format | Scientific Literature |