| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5130303 | B | Inhibition of human recombinant AKR1C1 transfected in Escherichia coli BL21 (DE3) pLysS competent cells assessed as inhibition of NADP+ dependent oxidation of S-tetralol using S-tetralol as substrate incubated for 10 mins by fluorescence microplate reader assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 2. | ALA5130304 | B | Inhibition of human recombinant AKR1C2 transfected in Escherichia coli BL21 (DE3) pLysS competent cells assessed as inhibition of NADP+ dependent oxidation of S-tetralol using S-tetralol as substrate incubated for 10 mins by fluorescence microplate reader assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 3. | ALA5130305 | B | Inhibition of human recombinant AKR1C3 transfected in Escherichia coli BL21 (DE3) pLysS competent cells assessed as inhibition of NADP+ dependent oxidation of S-tetralol using S-tetralol as substrate incubated for 10 mins by fluorescence microplate reader assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 4. | ALA5130306 | B | Inhibition of human recombinant AKR1C4 transfected in Escherichia coli BL21 (DE3) pLysS competent cells assessed as inhibition of NADP+ dependent oxidation of S-tetralol using S-tetralol as substrate incubated for 10 mins by fluorescence microplate reader assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 5. | ALA5130307 | B | Selectivity index, ratio of IC50 for inhibition of human recombinant AKR1C1 transfected in Escherichia coli BL21 (DE3) pLysS competent cells to IC50 for inhibition of human recombinant AKR1C3 transfected in Escherichia coli BL21 (DE3) pLysS competent cells | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 6. | ALA5130308 | B | Selectivity index, ratio of IC50 for inhibition of human recombinant AKR1C2 transfected in Escherichia coli BL21 (DE3) pLysS competent cells to IC50 for inhibition of human recombinant AKR1C3 transfected in Escherichia coli BL21 (DE3) pLysS competent cells | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 7. | ALA5130309 | B | Selectivity index, ratio of IC50 for inhibition of human recombinant AKR1C4 transfected in Escherichia coli BL21 (DE3) pLysS competent cells to IC50 for inhibition of human recombinant AKR1C3 transfected in Escherichia coli BL21 (DE3) pLysS competent cells | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 8. | ALA5130311 | F | Antiproliferative activity against human MCF7-DOX cells assessed as inhibition of cell growth at higher concentrations measured after 48 hrs by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA5130312 | F | Antiproliferative activity against human A549/DDP cells assessed as inhibition of cell growth at higher concentrations measured after 48 hrs by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA5130316 | F | Potentiation of doxorubicin induced antiproliferative activity against human MCF7-DOX cells assessed as reduction in cell viability at 50 to 200 uM incubated for 48 hrs in presence of 25 to 100 uM doxorubicin by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5130317 | F | Synergistic antiproliferative activity against human MCF7-DOX cells assessed as reduction in cell viability at 50 to 200 uM incubated for 48 hrs in presence of doxorubicin by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA5130323 | F | Synergistic antiproliferative activity against human A549/DDP cells assessed as reduction in cell viability at 50 to 200 uM incubated for 48 hrs in presence of cisplatin by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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