# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5133899 | A | Inhibition of CYP1A2 (unknown origin) assessed as residual activity at 20 uM by enzyme assay relative to control | Homo sapiens | 1 | ALA5131453 | single protein format | Scientific Literature | |
2. | ALA5133907 | B | Transactivation of Gal4-fused human PPARalpha expressed in CHO cells co expressing pG5-Luc reporter | Homo sapiens | 6 | ALA5131453 | cell-based format | Scientific Literature | |
3. | ALA5133908 | B | Transactivation of Gal4-fused human PPARgamma expressed in CHO cells co expressing pG5-Luc reporter | Homo sapiens | 7 | ALA5131453 | cell-based format | Scientific Literature | |
4. | ALA5133909 | B | Transactivation of Gal4-fused human PPARdelta expressed in CHO cells co expressing pG5-Luc reporter | Homo sapiens | 7 | ALA5131453 | cell-based format | Scientific Literature | |
5. | ALA5133910 | B | Transactivation of Gal4-fused mouse PPARdelta expressed in CHO cells co expressing pG5-Luc reporter | Mus musculus | 7 | ALA5131453 | cell-based format | Scientific Literature | |
6. | ALA5133911 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 0.5 hrs relative to control | Rattus norvegicus | 1 | ALA5131453 | microsome format | Scientific Literature | |
7. | ALA5133912 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 0.5 hrs relative to control | Homo sapiens | 1 | ALA5131453 | microsome format | Scientific Literature | |
8. | ALA5133913 | A | Inhibition of CYP2C9 (unknown origin) assessed as residual activity at 20 uM by enzyme assay relative to control | Homo sapiens | 1 | ALA5131453 | single protein format | Scientific Literature | |
9. | ALA5133914 | A | Inhibition of CYP2D6 (unknown origin) assessed as residual activity at 20 uM by enzyme assay relative to control | Homo sapiens | 1 | ALA5131453 | single protein format | Scientific Literature | |
10. | ALA5133915 | A | Inhibition of CYP3A4 (unknown origin) assessed as residual activity at 20 uM by enzyme assay relative to control | Homo sapiens | 1 | ALA5131453 | single protein format | Scientific Literature | |
11. | ALA5133916 | P | Kinetic solubility of compound at pH 6.8 by HPLC analysis | 1 | ALA5131453 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA5133917 | A | Total clearance in rat dosed as mixture | Rattus norvegicus | 1 | ALA5131453 | organism-based format | Scientific Literature | |
13. | ALA5133918 | A | Half life in rat dosed as mixture | Rattus norvegicus | 1 | ALA5131453 | organism-based format | Scientific Literature | |
14. | ALA5133919 | F | Anti-obesity activity in d/db mouse assessed as HDL cholesterol level at 30 mg/kg, po for 8 days (Rvb = 103.5 +/- 3.2 %) | Mus musculus | 2 | ALA5131453 | organism-based format | Scientific Literature | |
15. | ALA5133920 | F | Anti-obesity activity in d/db mouse assessed as TG level at 30 mg/kg, po for 8 days (Rvb = 162.8 +/- 21.4 mg/dL) | Mus musculus | 2 | ALA5131453 | organism-based format | Scientific Literature | |
16. | ALA5133921 | F | Anti-diabetic activity in d/db mouse assessed as glucose level at 30 mg/kg, po for 8 days (Rvb = 737 +/- 52 mg/dL) | Mus musculus | 2 | ALA5131453 | organism-based format | Scientific Literature | |
17. | ALA5133922 | B | Selectivity index, ratio of EC50 for human PPARalpha to EC50 for human PPARdelta | Homo sapiens | 1 | ALA5131453 | assay format | Scientific Literature | |
18. | ALA5133923 | B | Selectivity index, ratio of EC50 for human PPAgamma to EC50 for human PPARdelta | Homo sapiens | 1 | ALA5131453 | protein format | Scientific Literature | |
19. | ALA5265680 | B | Agonist activity at Gal4-fused human PPAR-delta ligand binding domain expressed in CHO-K1 cells assessed as receptor transactivation incubated for 24 to 48 hrs by luciferase reporter gene assay | Homo sapiens | 24 | ALA5260859 | cell-based format | Scientific Literature | |
20. | ALA5265681 | B | Agonist activity at Gal4-fused human PPAR-delta ligand binding domain expressed in CHO-K1 cells assessed as receptor transactivation incubated for 24 to 48 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 24 | ALA5260859 | cell-based format | Scientific Literature |