| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5168603 | F | Antifibrotic activity in bleomycin-induced Sprague-Dawley rat pulmonary fibrosis model assessed as decrease in relaxation time at 2.5 to 5 mg/kg, ip administered daily for 28 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5168604 | F | Antifibrotic activity in bleomycin-induced Sprague-Dawley rat pulmonary fibrosis model assessed as decrease in enhanced pause at 2.5 to 5 mg/kg, ip administered daily for 28 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5168605 | A | Half life in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA5168606 | F | Antifibrotic activity in bleomycin-induced Sprague-Dawley rat pulmonary fibrosis model assessed as decrease in end-expiratory pause at 2.5 to 5 mg/kg, ip administered daily for 28 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA5168607 | F | Antifibrotic activity in bleomycin-induced Sprague-Dawley rat pulmonary fibrosis model assessed as increase in respiratory rate at 2.5 to 5 mg/kg, ip administered daily for 28 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA5168608 | B | Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 7. | ALA5168610 | B | Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA5168611 | B | Inhibition of PDE1A (142 to 552 residues) (unknown origin) expressed in Escherichia coli BL21 measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA5168612 | B | Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA5168613 | B | Inhibition of PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA5168614 | B | Inhibition of PDE3A (679 to 1087 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA5168615 | B | Inhibition of PDE4B2 (152 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA5168616 | B | Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21 [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA5168617 | B | Inhibition of PDE7A1 (130-482 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA5168618 | B | Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA5168619 | B | Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA5168620 | B | Inhibition of PDE10A (449 to 770 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counter method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA5168621 | B | Selectivity ratio of IC50 for PDE1A (142 to 552 residues) (unknown origin) expressed in Escherichia coli BL21 to IC50 for PDE1C(147 TO 531 residue) (unknown origin) expressed in Escherichia coli BL21 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA5168622 | B | Selectivity ratio of IC50 for PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 to IC50 for PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA5168623 | B | Selectivity ratio of IC50 for PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL211 to IC50 for PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 | Homo sapiens | 1 | assay format | Scientific Literature |
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