| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5115858 | B | Binding affinity to wild type human partial length CDK11A (D391 to K730 residues) expressed in bacterial expression system assessed as dissociation constant by KdELECT assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA5115859 | B | Inhibition of N-terminus or C-terminus NLuc fused CDK11A (unknown origin) transfected in HEK293 cells by NanoBRET assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 3. | ALA5115860 | B | Inhibition of human recombinant full length GST-tagged CDK4/Cyclin D1 expressed in Baculovirus expression system by Adapta assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 4. | ALA5115861 | B | Inhibition of human recombinant full length GST-tagged CDK6/Cyclin D1 expressed in Baculovirus expression system by Adapta assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 5. | ALA5115862 | B | Inhibition of human recombinant full length His-tagged CDK9/Cyclin T1 expressed in Baculovirus expression system by Adapta assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 6. | ALA5115863 | B | Inhibition of N-terminus or C-terminus NLuc fused CDK4/Cyclin D1 (unknown origin) transfected in HEK293 cells by NanoBRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA5115864 | B | Inhibition of N-terminus or C-terminus NLuc fused CDK6/Cyclin D1 (unknown origin) transfected in HEK293 cells by NanoBRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA5115865 | B | Inhibition of N-terminus or C-terminus NLuc fused CDK9/Cyclin T1 (unknown origin) transfected in HEK293 cells by NanoBRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA5115866 | B | Inhibition of N-terminus or C-terminus NLuc fused CDK11B/Cyclin L2 (unknown origin) transfected in HEK293 cells by NanoBRET assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5115868 | B | Inhibition of CDK11 (unknown origin) expressed in human DLD-1 cells assessed as reduction in mRNA splicing by measuring increase in ratio of beta-galactosidase to luciferase activity at 10 uM incubated for 8 hrs by microplate analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5115869 | F | Induction of cell cycle arrest in thymidine synchronized human A-375 cells assessed as accumulation at G2/M phase at 5 to 10 uM incubated for 10 hrs by RNaseA/propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5115877 | F | Antiproliferative activity against human A-375 cells harboring CDK11B-G579S mutant assessed as cell growth inhibition measured after 72 hrs by Cell Titer-Glo assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
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