# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5163568 | F | Suppression of renal cyst development in embryonic kidney of 8-Br-cAMP induced C57BL/6 mouse mouse model of autosomal dominant polycystic kidney disease assessed as residence time dependent measured after 8 days | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
2. | ALA5163569 | B | Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after 2 hrs by HTRF assay | Homo sapiens | 10 | ALA5154831 | cell-based format | Scientific Literature | |
3. | ALA5163570 | B | Inhibition of conivaptan-red binding to SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as binding constant (Kon) measured after 2 hrs by HTRF competitive binding assay | Homo sapiens | 10 | ALA5154831 | cell-based format | Scientific Literature | |
4. | ALA5163571 | B | Inhibition of conivaptan-red binding to SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as binding constant (Koff) measured after 2 hrs by HTRF competitive binding assay | Homo sapiens | 10 | ALA5154831 | cell-based format | Scientific Literature | |
5. | ALA5163572 | B | Inhibition of conivaptan-red binding to SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as residence time (1/koff) measured after 2 hrs by HTRF competitive binding assay | Homo sapiens | 10 | ALA5154831 | cell-based format | Scientific Literature | |
6. | ALA5163578 | F | Suppression of renal cyst development in embryonic kidney of 8-Br-cAMP induced C57BL/6 mouse mouse model of autosomal dominant polycystic kidney disease measured after 8 days | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
7. | ALA5163579 | F | Invivo antagonist activity at V2R in Pkd1 knockout mouse model of autosomal dominant polycystic kidney disease assessed as reduction in kidney size at 2 mg/kg, sc administered once daily treatment started from postnatal day 6 to 12 days | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
8. | ALA5163580 | T | Toxicity in wild type mouse assessed as effect on kidney size | Mus musculus | 10 | ALA5154831 | tissue-based format | Scientific Literature | |
9. | ALA5163581 | T | Toxicity in wild type mouse assessed as effect on body weight | Mus musculus | 10 | ALA5154831 | assay format | Scientific Literature | |
10. | ALA5163583 | A | Elimination rate constant in C57BL/6 mouse at 2 mg/kg, sc by LC-MS analysis | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
11. | ALA5163584 | A | Half life in C57BL/6 mouse at 2 mg/kg, sc by LC-MS analysis | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
12. | ALA5163585 | A | Tmax in C57BL/6 mouse at 2 mg/kg, sc by LC-MS analysis | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
13. | ALA5163586 | A | Cmax in C57BL/6 mouse at 2 mg/kg, sc by LC-MS analysis | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
14. | ALA5163587 | A | AUC (0 to t) in C57BL/6 mouse at 2 mg/kg, sc by LC-MS analysis | Mus musculus | 10 | ALA5154831 | organism-based format | Scientific Literature | |
15. | ALA5163588 | P | Equilibrium solubility of compound in water incubated for 24 hrs by UV-spectroscopy method | 10 | ALA5154831 | small-molecule physicochemical format | Scientific Literature |