# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5116236 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as Akt degradation at 250 nM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA5113422 | cell-based format | Scientific Literature | |
2. | ALA5116238 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as Akt degradation after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
3. | ALA5116239 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as Akt degradation at 250 nM after 2 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
4. | ALA5116240 | B | Protac activity at CRBN/Akt1 in human Jeko-1 cells assessed as Akt1 degradation at 500 nM after 12 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
5. | ALA5116241 | B | Protac activity at CRBN/Akt2 in human Jeko-1 cells assessed as Akt2 degradation at 500 nM after 12 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
6. | ALA5116242 | B | Protac activity at CRBN/IKZF3 in human Jeko-1 cells assessed as IKZF3 degradation at 500 nM after 12 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
7. | ALA5116243 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as Akt degradation at 250 nM cotreated with proteasome inhibitor Bortezomib by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
8. | ALA5116244 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as Akt degradation at 250 nM cotreated with NEDD activating enzyme MLN4924 by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
9. | ALA5116245 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as decrease in phosphorylated GSK3beta level after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
10. | ALA5116246 | F | Antiproliferative activity against human Jeko-1 cells assessed as cell viability measured after 7 days by CCK-8 assay | Homo sapiens | 5 | ALA5113422 | cell-based format | Scientific Literature | |
11. | ALA5116247 | F | Antiproliferative activity against human Jeko-1 cells expressing CRBN-knockout assessed as cell viability measured after 7 days by CCK-8 assay | Homo sapiens | 5 | ALA5113422 | cell-based format | Scientific Literature | |
12. | ALA5116248 | F | Antiproliferative activity against human Mino cells assessed as cell viability measured after 7 days by CCK-8 assay | Homo sapiens | 5 | ALA5113422 | cell-based format | Scientific Literature | |
13. | ALA5116249 | F | Antiproliferative activity against human MM1.S cells assessed as cell viability measured after 3 days by CCK-8 assay | Homo sapiens | 5 | ALA5113422 | cell-based format | Scientific Literature | |
14. | ALA5116250 | F | Antiproliferative activity against human MM1.S cells assessed as cell viability measured after 7 days by CCK-8 assay | Homo sapiens | 5 | ALA5113422 | cell-based format | Scientific Literature | |
15. | ALA5116251 | F | Antiproliferative activity against human Jeko-1 cells assessed as cell viability measured after 3 days cotreated with Ibrutinib by CCK-8 assay | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature | |
16. | ALA5116252 | B | Protac activity at CRBN/Akt in human Jeko-1 cells assessed as decrease in Myc level after 24 hrs cotreated with Ibrutinib by immunoblot analysis | Homo sapiens | 1 | ALA5113422 | cell-based format | Scientific Literature |