| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5107733 | B | Inhibition of HDAC3-SMRT (unknown origin) using Boc-(Ac)Lys-AMC as substrate preincubated with compound for 1 hrs followed by substrate addition and measured after 1 hrs by fluorescent assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 2. | ALA5107735 | B | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA5107736 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA5107737 | B | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5107739 | B | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC3 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5107742 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA5107743 | B | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5107744 | B | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA5107745 | B | Inhibition of class I HDAC in human HCT-116 cells nucleus extract assessed as fold change in H3K56 acetylation level at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 10. | ALA5107746 | B | Inhibition of class I HDAC in human HCT-116 cells nucleus extract assessed as fold change in H3K56 acetylation level at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 11. | ALA5107747 | B | Inhibition of class I HDAC in human HCT-116 cells nucleus extract assessed as fold change in H3K56 acetylation level at 0.1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 12. | ALA5107749 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA5107750 | B | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA5107752 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 2.5 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5107753 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 0.01 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5107754 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 0.025 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5107755 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 0.05 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5107756 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5107757 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 0.1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5107758 | B | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as HDAC1 level at 0.25 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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