# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5107734 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5104222 | cell-based format | Scientific Literature | |
2. | ALA5107735 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
3. | ALA5107741 | Binding | Inhibition of class I HDAC in human HCT-116 cells nucleus extract assessed as increase in H3K56 acetylation level at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | subcellular format | Scientific Literature | |
4. | ALA5107742 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
5. | ALA5107743 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
6. | ALA5107744 | Binding | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
7. | ALA5107749 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
8. | ALA5107750 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
9. | ALA5107751 | Binding | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC3 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature |