| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5130499 | B | Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assay | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 2. | ALA5130500 | A | Inhibition of human recombinant CYP2C9 using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and measured after 20 to 50 mins by fluorescence based method | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA5130501 | B | Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA5130502 | B | Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by chemiluminescence assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA5130503 | B | Selectivity ratio of IC50 for human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells to IC50 for MPO in human HL-60 cells | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA5130504 | B | Irreversible inhibition of MPO (unknown origin) assessed as fold shift in EC50 incubated with compound followed by drug washing and later treated with H2O2 for enzyme reactivation by chemiluminescence assay | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 7. | ALA5130508 | P | Lipophilicity, log D of the compound | 14 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5130509 | P | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 incubated for 18 hrs by shake flask method | 14 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA5130510 | A | Intrinsic clearance in human liver microsomes at 1 uM measured up to 30 mins in presence of NADPH measured per mg protein by LC-MS/MS analysis | Homo sapiens | 14 | microsome format | Scientific Literature | ||
| 10. | ALA5130511 | A | Intrinsic clearance in Wistar Han rat hepatocytes at 1 uM measured up to 120 mins measured per 10^6 cells by LC-MS/MS analysis | Rattus norvegicus | 14 | cell-based format | Scientific Literature | ||
| 11. | ALA5130512 | A | Intrinsic clearance in human hepatocytes at 1 uM measured up to 120 mins measured per 10^6 cells by LC-MS/MS analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 12. | ALA5130513 | A | Apparent permeability of the compound across apical to basolateral side in human Caco-2 cells at 10 uM by LC-MS/MS analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 13. | ALA5130514 | T | Inhibition of hERG | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 14. | ALA5130515 | A | Inhibition of CYP2D6 (unknown origin) using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and measured after 20 to 50 mins by fluorescence based method | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA5130516 | A | Inhibition of human recombinant CYP1A2 using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and measured after 20 to 50 mins by fluorescence based method | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 16. | ALA5130517 | A | Inhibition of human recombinant CYP2C19 using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and measured after 20 to 50 mins by fluorescence based method | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 17. | ALA5130518 | A | Competitive inhibition of human recombinant CYP3A4 using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and measured after 20 to 50 mins by fluorescence based method | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 18. | ALA5130519 | A | Clearance in Wistar Han rat administered po or iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 19. | ALA5130520 | A | Oral bioavailability in Wistar Han rat measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 20. | ALA5130524 | A | Time-dependent inhibition of human recombinant CYP3A4 using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and measured after 20 to 50 mins by fluorescence based method | Homo sapiens | 3 | single protein format | Scientific Literature |
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