# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5100219 | Binding | Inhibition of TRKB (unknown origin) | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
2. | ALA5100220 | ADME | AUC(0 to t) in Sprague-Dawley rat at 10 mg/kg, ip measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5096238 | organism-based format | Scientific Literature | |
3. | ALA5100221 | ADME | AUC(0 to t) in Sprague-Dawley rat at 10 mg/kg, po measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5096238 | organism-based format | Scientific Literature | |
4. | ALA5100222 | ADME | AUC(0 to t) in Sprague-Dawley rat at 2 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5096238 | organism-based format | Scientific Literature | |
5. | ALA5100223 | Binding | Inhibition of N-terminal His/SUMO tagged wild type human c-Met (1038 to 1346 residues) transfected in Escherichia coli using Tyr06 peptide as substrate incubated for 1 hr in presence of ATP by FRET-based Z'-Lyte assay | Homo sapiens | 51 | ALA5096238 | assay format | Scientific Literature | |
6. | ALA5100224 | Functional | Antiproliferative activity against human Hs746T cells harboring MET alterations assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay | Homo sapiens | 41 | ALA5096238 | cell-based format | Scientific Literature | |
7. | ALA5100226 | Binding | Inhibition of AXL (unknown origin) | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
8. | ALA5100227 | Binding | Inhibition of TRKA (unknown origin) | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
9. | ALA5100228 | ADME | Apparent permeability across apical to basolateral side in human Caco-2 cells at 10 uM incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5096238 | cell-based format | Scientific Literature | |
10. | ALA5100229 | Binding | Inhibition of AXL (unknown origin) at 1000 nM relative to control | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
11. | ALA5100230 | Binding | Inhibition of TRKA (unknown origin) at 1000 nM relative to control | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
12. | ALA5100231 | Binding | Inhibition of TRKB (unknown origin) at 1000 nM relative to control | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
13. | ALA5100232 | Binding | Inhibition of TRKC (unknown origin) at 1000 nM relative to control | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
14. | ALA5100233 | Binding | Inhibition of TRKC (unknown origin) | Homo sapiens | 2 | ALA5096238 | single protein format | Scientific Literature | |
15. | ALA5100234 | Functional | Antiproliferative activity against mouse BaF3 cells harboring wild type Tpr-Met fusion protein assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay | Mus musculus | 2 | ALA5096238 | cell-based format | Scientific Literature | |
16. | ALA5100235 | Functional | Antiproliferative activity against mouse BaF3 cells harboring Tpr-Met fusion protein F1200L mutant assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay | Mus musculus | 2 | ALA5096238 | cell-based format | Scientific Literature | |
17. | ALA5100236 | Functional | Antiproliferative activity against mouse BaF3 cells harboring Tpr-Met fusion protein M1250T mutant assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay | Mus musculus | 2 | ALA5096238 | cell-based format | Scientific Literature | |
18. | ALA5100237 | Functional | Antiproliferative activity against mouse BaF3 cells harboring Tpr-Met fusion protein H1094Y mutant assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay | Mus musculus | 2 | ALA5096238 | cell-based format | Scientific Literature | |
19. | ALA5100238 | Functional | Antiproliferative activity against mouse BaF3 cells harboring Tpr-Met fusion protein F1200I mutant assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay | Mus musculus | 2 | ALA5096238 | cell-based format | Scientific Literature | |
20. | ALA5100239 | Functional | Antiproliferative activity against mouse BaF3 cells harboring Tpr-Met fusion protein L1195V mutant assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay | Mus musculus | 2 | ALA5096238 | cell-based format | Scientific Literature |