| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5161275 | B | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced Ca2+ influx at 10 uM incubated for 30 mins by FLIPR method | Homo sapiens | 83 | cell-based format | Scientific Literature | ||
| 2. | ALA5161276 | B | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced Ca2+ influx incubated for 30 mins by FLIPR method | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 3. | ALA5161277 | B | Antagonist activity at human TRPV1 expressed in CHO cells assessed as low pH-induced Ca2+ influx at 10 uM incubated for 30 mins at pH 5 by FLIPR method | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 4. | ALA5161278 | F | Analgesic activity against capsaicin-induced pain mouse model assessed as reduction in time spent on foot licking behaviour at 10 mg/kg, ip administered 30 mins prior to capsaicin stimulation and measured after 5 mins | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 5. | ALA5161279 | F | Antinociceptive activity in mouse assessed as reduction in acetic acid induced writhing response at 10 mg/kg, ip administered 30 mins prior to acetic acid administration and measured every 15 mins by abdominal constriction test | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 6. | ALA5161280 | F | Antinociceptive activity against thermal-induced nociception mouse model assessed as increase in tail withdrawal latency at 10 mg/kg, ip measured after 30 mins by tail flick test | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 7. | ALA5161281 | F | Analgesic activity against ip dosed capsaicin-induced pain mouse model assessed as reduction in time spent on foot licking behaviour administered 30 mins prior to capsaicin stimulation and measured after 5 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5161282 | F | Antinociceptive activity in mouse assessed as reduction in acetic acid induced writhing response at 3 to 30 mg/kg, ip administered 30 mins prior to acetic acid administration and measured every 15 mins by abdominal constriction test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5161283 | F | Antinociceptive activity against thermal-induced nociception mouse model assessed as increase in latency time of nociceptive response at 10 to 30 mg/kg, ip measured after 30 mins by tail flick test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5161284 | T | Toxicity in rat assessed as increase in body temperature at 30 mg/kg, po measured for 180 mins by electric probe thermometer analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA5161285 | T | Toxicity in rat assessed as effect on body temperature at 10 to 100 mg/kg, po measured for 120 mins by electric probe thermometer analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5161286 | A | Half life in Sprague-Dawley rat at 10 mg/kg, iv measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5161287 | A | Absorption rate constant half life (ka) in Sprague-Dawley rat at 20 mg/kg, po measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5161288 | A | Elimination rate constant half life (k10) in Sprague-Dawley rat at 20 mg/kg, po measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5161289 | A | Volume of distribution in Sprague-Dawley rat at 10 mg/kg, iv measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5161290 | A | Volume of distribution in Sprague-Dawley rat at 20 mg/kg, po measured after 12 hrs post dose by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5161291 | A | Tmax in Sprague-Dawley rat at 20 mg/kg, po measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5161292 | A | Cmax in Sprague-Dawley rat at 20 mg/kg, po measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5161293 | A | Clearance in Sprague-Dawley rat at 10 mg/kg, iv measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5161294 | A | Clearance in Sprague-Dawley rat at 20 mg/kg, po measured after 12 hrs by UPLC-QTOF/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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