# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5165098 | Functional | Antiproliferative activity against human BRCA1 -/- MDA-MB-436 cells assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 30 | ALA5154873 | cell-based format | Scientific Literature | |
2. | ALA5165099 | Functional | Antiproliferative activity against human BRCA2 -/- CAPAN-1 cells assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 30 | ALA5154873 | cell-based format | Scientific Literature | |
3. | ALA5165100 | Functional | Antiproliferative activity against human PTEN -/- MDA-MB-468 cells assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 30 | ALA5154873 | cell-based format | Scientific Literature | |
4. | ALA5165101 | Functional | Antiproliferative activity against wild type human MDA-MB-231 cells assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 30 | ALA5154873 | cell-based format | Scientific Literature | |
5. | ALA5165103 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation at 1 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 18 | ALA5154873 | cell-based format | Scientific Literature | |
6. | ALA5165104 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
7. | ALA5165105 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as maximum degradation of PARP2 measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
8. | ALA5165107 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation at 0.5 uM measured after 24 hrs in presence of MG132 by Western blot analysis | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
9. | ALA5165108 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation at 0.5 uM measured after 24 hrs in presence of olaparib by Western blot analysis | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
10. | ALA5165109 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation at 0.5 uM measured after 24 hrs in presence of KB02 by Western blot analysis | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
11. | ALA5165110 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation at 0.5 uM measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
12. | ALA5165111 | Binding | Protac activity at DCAF16 E3 ligase/PARP2 in human MDA-MB-231 cells assessed as induction of PARP2 degradation at 0.5 uM preincubated for 2 hrs followed by compound washout measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
13. | ALA5165112 | Binding | Inhibition of PARP1 (unknown origin) | Homo sapiens | 2 | ALA5154873 | single protein format | Scientific Literature | |
14. | ALA5165113 | Binding | Inhibition of PARP2 (unknown origin) | Homo sapiens | 2 | ALA5154873 | single protein format | Scientific Literature | |
15. | ALA5165114 | Functional | Antiproliferative activity against human HeLa cells over expressing DCAF16 assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
16. | ALA5165115 | Functional | Antiproliferative activity against human HepG2 cells over expressing DCAF16 assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
17. | ALA5165116 | Functional | Antiproliferative activity against human SK-OV-3 cells over expressing DCAF16 assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
18. | ALA5165117 | Functional | Antiproliferative activity against human H2228 cells over expressing DCAF16 assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
19. | ALA5165118 | Functional | Antiproliferative activity against human H3122 cells over expressing DCAF16 assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature | |
20. | ALA5165119 | Functional | Antiproliferative activity against human SW-620 cells over expressing DCAF16 assessed as reduction in cell viability incubated for 5 to 10 days by MTT assay | Homo sapiens | 1 | ALA5154873 | cell-based format | Scientific Literature |