| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149698 | B | Activation of human Slo G803D/N806K mutant expressed in human AD293 cells assessed as initial velocity of channel activation at 6 uM measured at 2 secs interval for 4 secs by FluxOR based fluorescence assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA5149699 | B | Activation of human Slo G803D/N806K mutant expressed in human AD293 cells assessed as increase in initial velocity at 5 uM measured at 2 secs interval for 4 secs by FluxOR based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5149700 | B | Activation of human Slo G803D/N806K mutant expressed in human AD293 cells measured at 2 secs interval for 120 secs by FluxOR based fluorescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA5149701 | B | Activation of human Slo G803D/N806K mutant expressed in human AD293 cells assessed as increase in channel activity by measuring change in relative fluorescence unit at 6 uM measured at 2 secs interval for 80 secs by FluxOR based fluorescence assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 5. | ALA5149702 | A | Stability in human liver microsomes assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 6. | ALA5149703 | B | Activation of human Slo G803D/N806K mutant expressed in human AD293 cells assessed as increase in initial velocity at 1 uM measured at 2 secs interval for 120 secs by FluxOR based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5149704 | B | Activation of rat Slo expressed in Xenopus laevis oocytes at 10 uM with 100 mV holding potential by patch-clamp electrophysiological method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5149705 | B | Activation of rat Slo expressed in Xenopus laevis oocytes assessed as shift in voltage at half activation at 10 uM with 100 mV holding potential by patch-clamp electrophysiological method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5149706 | B | Activation of rat Slo expressed in Xenopus laevis oocytes assessed as increase in maximum conductance at 10 uM with 100 mV holding potential by patch-clamp electrophysiological method relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5149707 | B | Activation of rat Slo expressed in Xenopus laevis oocytes assessed as intracellular shift in voltage at half activation at 10 uM with 100 mV holding potential by patch-clamp electrophysiological method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5149708 | B | Activation of rat Slo expressed in Xenopus laevis oocytes assessed as increase in intracellular maximum conductance at 10 uM with 100 mV holding potential by patch-clamp electrophysiological method relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5149709 | B | Activation of rat Slo expressed in Xenopus laevis oocytes assessed as shortened channel opening 10 uM with 100 mV holding potential by patch-clamp electrophysiological method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5149710 | B | Activation of rat Slo expressed in Xenopus laevis oocytes assessed as delayed channel closing 10 uM with 100 mV holding potential by patch-clamp electrophysiological method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5149711 | A | Half life in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5149712 | A | AUC (0 to 8 hrs) in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5149713 | A | AUC (infinity) in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5149714 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5149715 | A | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5149716 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5149717 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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