| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5165901 | B | Inhibition of human recombinant CDK5/p25 expressed in bacterial expression system assessed as residual activity at 1 uM using histone H1 as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 2. | ALA5165903 | B | Inhibition of recombinant human Haspin (470 to 798 residues) expressed in bacterial expression system assessed as residual activity at 1 uM using ARTKQTARKSTGGKAPRKQLA as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 3. | ALA5165904 | B | Inhibition of recombinant human Haspin (470 to 798 residues) expressed in bacterial expression system using ARTKQTARKSTGGKAPRKQLA as substrate measured after 30 mins in presence of ATP by ADP-Glo assay | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 4. | ALA5165905 | B | Inhibition of recombinant mouse CLK1 expressed in bacteria assessed as residual activity at 1 uM using GRSRSRSRSRSR as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Mus musculus | 20 | assay format | Scientific Literature | ||
| 5. | ALA5165906 | B | Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of ATP measured after 30 mins by ADP-Glo assay | Mus musculus | 9 | assay format | Scientific Literature | ||
| 6. | ALA5165907 | B | Inhibition of recombinant rat DYRK1A (1 to 499 residues) expressed in bacterial expression system assessed as residual activity at 1 uM using KKISGRLSPIMTEQ as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Rattus norvegicus | 20 | assay format | Scientific Literature | ||
| 7. | ALA5165908 | B | Inhibition of recombinant rat DYRK1A (1 to 499 residues ) expressed in bacterial expression system using KKISGRLSPIMTEQ as substrate measured after 30 mins in presence of ATP by ADP-Glo assay | Rattus norvegicus | 9 | assay format | Scientific Literature | ||
| 8. | ALA5165909 | B | Inhibition of human recombinant CDK9/CyclinT expressed in baculovirus insect Sf9 cells assessed as residual activity at 1 uM using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 9. | ALA5165910 | B | Inhibition of human recombinant CDK9 expressed in baculovirus insect Sf9 cells using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate measured after 30 mins in presence of ATP by ADP-Glo assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA5165911 | B | Inhibition of human recombinant GSK3beta expressed in baculovirus in Sf9 insect cells assessed as residual activity at 1 uM using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate measured after 30 mins in presence of ATP by ADP-Glo kinase assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 11. | ALA5165913 | B | Inhibition of human recombinant CK1 epsilon expressed in baculovirus in sf9 insect cells assessed as residual activity at 1 uM using RRKHAAIGSpAYSITA as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 12. | ALA5165916 | B | Inhibition of recombinant human PIM1 expressed in bacterial expression system assessed as residual activity at 1 uM using histone H1 as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 13. | ALA5165917 | B | Inhibition of human recombinant ABL1 expressed in baculovirus sf9 insect cells assessed as residual activity at 1 uM using EAIYAAPFAKKK as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 14. | ALA5165919 | B | Inhibition of human recombinant JAK3 expressed in baculovirus sf9 insect cells assessed as residual activity at 1 uM using GGEEEEYFELVKKKK as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 15. | ALA5165921 | B | Selectivity index, ratio of IC50 for recombinant mouse CLK1 expressed in bacteria to IC50 for recombinant human Haspin (470 to 798 residues) expressed in bacterial expression system | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 16. | ALA5165922 | F | Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA5165923 | T | Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA5165924 | F | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA5165925 | F | Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA5165926 | F | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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