# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5161544 | T | Cytotoxicity against golden hamster BSR cells assessed as reduction in cell viability incubated for 24 hrs by microplate luminometer method | Mesocricetus auratus | 33 | ALA5154797 | cell-based format | Scientific Literature | |
2. | ALA5161545 | F | Antirabies activity against rabies CVS infected in golden hamster BSR cells preincubated for 1 hr followed by mixing of cells measured after 24 hrs by inverted fluorescence microscope analysis | Lyssavirus rabies | 33 | ALA5154797 | organism-based format | Scientific Literature | |
3. | ALA5161546 | T | Selectivity index, ratio of CC50 for cytotoxicity against golden hamster BSR cells to EC50 for antirabies activity against Rabies virus infected in golden hamster BSR cells | 33 | ALA5154797 | cell-based format | Scientific Literature | ||
4. | ALA5161547 | F | Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 24 hrs by microplate reader assay | Homo sapiens | 32 | ALA5154797 | cell-based format | Scientific Literature | |
5. | ALA5161548 | F | Antiviral activity against S-protein based pseudotyped SARS-CoV-2 infected in Huh7 cells measured after 24 hrs by bright-Glo luciferase assay | Severe acute respiratory syndrome coronavirus 2 | 31 | ALA5154797 | organism-based format | Scientific Literature | |
6. | ALA5161549 | F | Selectivity index, ratio of CC50 for cytotoxicity against human Huh7 cells to EC50 for antiviral activity against S-protein based pseudotyped SARS-CoV-2 infected in Huh7 cells | 27 | ALA5154797 | cell-based format | Scientific Literature | ||
7. | ALA5161550 | T | Acute toxicity in Kunming mouse assessed as lethal dose administered orally measured after 7 days | Mus musculus | 2 | ALA5154797 | assay format | Scientific Literature | |
8. | ALA5161551 | B | Binding affinity to SARS-CoV-2 spike protein assessed as Kd by SPR analysis | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5154797 | single protein format | Scientific Literature | |
9. | ALA5161552 | F | Antirabies activity against rabies CVS infected in golden hamster BSR cells assessed as inhibition of viral growth at 25 uM treated 1 hr post infection measured after 23 hrs by measuring luciferase signal | Lyssavirus rabies | 2 | ALA5154797 | organism-based format | Scientific Literature | |
10. | ALA5161553 | B | Binding affinity to rabies recombinant GST-His-tagged G-glycoprotein protein (20 to 459 AA residues) expressed in Escherichia coli BL21 (DE3) cells assessed as Kd treated for 60 secs followed dissociation time of 120 secs by SPR analysis | Lyssavirus rabies | 2 | ALA5154797 | cell-based format | Scientific Literature | |
11. | ALA5161554 | B | Binding affinity to SARS-CoV-2 spike protein at 0.16 to 5 uM by SPR analysis | Severe acute respiratory syndrome coronavirus 2 | 1 | ALA5154797 | single protein format | Scientific Literature |