# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5129507 | F | Antiviral activity against Hepatitis B virus infected in human HepG2 cells expressing NTCP assessed as inhibition of viral entry by measuring intracellular HBV DNA at 1 uM preincubated with compound for 2 hrs followed by viral infection and measured after 3 hrs by qPCR analysis relative to control | Hepatitis B virus | 24 | ALA5126594 | organism-based format | Scientific Literature | |
2. | ALA5129508 | F | Antiviral activity against Hepatitis B virus infected in human HepG2 cells expressing NTCP assessed as inhibition of viral entry by measuring intracellular HBV DNA preincubated with compound for 2 hrs followed by viral infection and measured after 3 hrs by qPCR analysis | Hepatitis B virus | 6 | ALA5126594 | organism-based format | Scientific Literature | |
3. | ALA5129509 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay | Homo sapiens | 3 | ALA5126594 | cell-based format | Scientific Literature | |
4. | ALA5151419 | A | Permeability in PBS buffer measured after 18 hrs by PAMPA based LC-MS analysis | 6 | ALA5149989 | assay format | Scientific Literature | ||
5. | ALA5151420 | A | Effective permeability in PBS buffer assessed as mass retention measured after 18 hrs by PAMPA based LC-MS analysis | 5 | ALA5149989 | assay format | Scientific Literature | ||
6. | ALA5151421 | A | Permeability across apical to basal side in human Caco-2 cells measured at 0.5 to 2 hrs by LC-MS analysis | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
7. | ALA5151422 | A | Permeability across apical to basal side in human Caco-2 cells assessed as drug recovery measured at 0.5 to 2 hrs by LC-MS analysis relative to control | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
8. | ALA5151423 | A | Permeability across basal to apical side in human Caco-2 cells measured at 0.5 to 2 hrs by LC-MS analysis | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
9. | ALA5151424 | A | Permeability across basal to apical side in human Caco-2 cells assessed as drug recovery measured at 0.5 to 2 hrs by LC-MS analysis relative to control | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
10. | ALA5151425 | A | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side in human Caco2 cells measured at 0.5 to 2 hrs by LC-MS analysis | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
11. | ALA5151426 | A | Permeability across apical to basal side in human Caco-2 cells preincubated with verapamil for 30 mins followed by compound addition measured at 0.5 to 2 hrs by LC-MS analysis | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
12. | ALA5151427 | A | Permeability across apical to basal side in human Caco-2 cells assessed as drug recovery preincubated with verapamil for 30 mins followed by compound addition measured at 0.5 to 2 hrs by LC-MS analysis relative to control | Homo sapiens | 7 | ALA5149989 | cell-based format | Scientific Literature | |
13. | ALA5151429 | A | Tmax in ICR mouse at 20 mg/kg, po measured after 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5149989 | organism-based format | Scientific Literature | |
14. | ALA5151430 | A | AUCinfinity in ICR mouse at 20 mg/kg, po measured after 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5149989 | organism-based format | Scientific Literature | |
15. | ALA5151431 | A | Cmax in ICR mouse at 20 mg/kg, po measured after 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5149989 | organism-based format | Scientific Literature | |
16. | ALA5151432 | A | Clearance in ICR mouse at 20 mg/kg, po measured after 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5149989 | organism-based format | Scientific Literature | |
17. | ALA5151433 | A | Apparent volume of distribution in ICR mouse at 20 mg/kg, po measured after 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5149989 | organism-based format | Scientific Literature | |
18. | ALA5151434 | A | Half life in ICR mouse at 20 mg/kg, po measured after 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5149989 | organism-based format | Scientific Literature | |
19. | ALA5151435 | A | AUCinfinity in ICR mouse at 20 mg/kg, iv measured after 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5149989 | organism-based format | Scientific Literature | |
20. | ALA5151436 | A | Clearance in ICR mouse at 20 mg/kg, iv measured after 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5149989 | organism-based format | Scientific Literature |