| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5132368 | T | Chronic toxicity in rat assessed as increase in relative kidney weight at 18.75 mg/kg, iv administered as pluronic F127 formulation at 4 intervals for 21 days and observed 3 weeks post last injection | Rattus norvegicus | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 2. | ALA5132369 | F | Cytotoxicity against human 22Rv1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 4 | ALA5131389 | cell-based format | Scientific Literature | |
| 3. | ALA5132370 | F | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 4 | ALA5131389 | cell-based format | Scientific Literature | |
| 4. | ALA5132371 | U | Selectivity ratio of CC50 for cytotoxicity against human PC-3 cells to CC50 for cytotoxicity against human 22Rv1 cells | 4 | ALA5131389 | cell-based format | Scientific Literature | ||
| 5. | ALA5132372 | F | Induction of ROS generation in human 22Rv1 cells at 800 mV holding potential measured after 1 hr by patch clamp amplifier based optical inverted microscopic analysis | Homo sapiens | 2 | ALA5131389 | cell-based format | Scientific Literature | |
| 6. | ALA5132373 | F | Induction of ROS generation in human PC-3 cells at 800 mV holding potential measured after 1 hr by patch clamp amplifier based optical inverted microscopic analysis | Homo sapiens | 2 | ALA5131389 | cell-based format | Scientific Literature | |
| 7. | ALA5132375 | F | Effect on cell stiffness in human 22Rv1 cells assessed as increase in young's modulus at 2.7 nM measured after 1 hr by topography based scanning ion-conductance microscopic analysis | Homo sapiens | 1 | ALA5131389 | cell-based format | Scientific Literature | |
| 8. | ALA5132377 | F | Effect on cell stiffness in human PC-3 cells assessed as increase in young's modulus at 2.8 nM measured after 1 hr by topography based scanning ion-conductance microscopic analysis | Homo sapiens | 1 | ALA5131389 | cell-based format | Scientific Literature | |
| 9. | ALA5132378 | A | Stability of the compound in porcine liver esterase assessed as compound remaining measured upto 96 hrs by LCMS based mass spectrometric analysis relative to initial amount | 1 | ALA5131389 | assay format | Scientific Literature | ||
| 10. | ALA5132379 | P | Stability of the compound in pH 5.5 buffer measured upto 96 hrs by LC-MS based mass spectrometric analysis | 1 | ALA5131389 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA5132380 | P | Stability of the compound in pH 7.4 buffer measured upto 96 hrs by LC-MS based mass spectrometric analysis | 1 | ALA5131389 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA5132382 | T | Chronic toxicity in rat assessed as increase in creatinine concentration at 18.75 to 22.5 mg/kg, iv administered as pluronic F127 formulation at 4 intervals for 21 days and observed 3 weeks post last injection relative to control | Rattus norvegicus | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 13. | ALA5132383 | P | Aqueous solubility of compound | 2 | ALA5131389 | small-molecule physicochemical format | Scientific Literature | ||
| 14. | ALA5132384 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 30 mg/kg, ip administered daily for 5 days and measured at day 34 relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 15. | ALA5132386 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 10 mg/kg, ip administered once in two days for three times and measured 1 day after the end of treatment relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 16. | ALA5132387 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 20 mg/kg, ip administered once in two days for three times and measured 1 day after the end of treatment relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 17. | ALA5132388 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 10 mg/kg, ip administered once in two days for three times and measured 4 days after the end of treatment relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 18. | ALA5132389 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 20 mg/kg, ip administered once in two days for three times and measured 4 days after the end of treatment relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 19. | ALA5132390 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 10 mg/kg, ip administered once in two days for three times and measured 7 days after the end of treatment relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature | |
| 20. | ALA5132391 | F | Antitumor activity against human 22Rv1 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 20 mg/kg, ip administered once in two days for three times and measured 7 days after the end of treatment relative to control | Homo sapiens | 1 | ALA5131389 | organism-based format | Scientific Literature |
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