| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5139763 | B | Inhibition of N-terminal human TRKA (436 to 790 residues) expressed in baculovirus expression system using TK as substrate measured after 30 mins in presence of ATP by HTRF assay | Homo sapiens | 39 | ALA5137027 | assay format | Scientific Literature | |
| 2. | ALA5139764 | B | Inhibition of N-terminal human TRKB (456 to 822 residues) expressed in baculovirus expression system using TK as substrate measured after 40 mins in presence of ATP by HTRF assay | Homo sapiens | 7 | ALA5137027 | assay format | Scientific Literature | |
| 3. | ALA5139765 | B | Inhibition of N-terminal human TRKC (456 to 825 residues) expressed in baculovirus expression system using TK as substrate measured after 40 mins in presence of ATP by HTRF assay | Homo sapiens | 7 | ALA5137027 | assay format | Scientific Literature | |
| 4. | ALA5139766 | A | Metabolic stability in human liver microsomes assessed as half life at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5137027 | microsome format | Scientific Literature | |
| 5. | ALA5139767 | A | Metabolic stability in human microsomes assessed as intrinsic clearance at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5137027 | microsome format | Scientific Literature | |
| 6. | ALA5139768 | A | Metabolic stability in human liver assessed as intrinsic clearance at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5137027 | tissue-based format | Scientific Literature | |
| 7. | ALA5139769 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5137027 | microsome format | Scientific Literature | |
| 8. | ALA5139770 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 100 uM incubated for 60 mins under shaking condition in absence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5137027 | microsome format | Scientific Literature | |
| 9. | ALA5139771 | F | Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | ALA5137027 | cell-based format | Scientific Literature | |
| 10. | ALA5139772 | F | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 6 | ALA5137027 | cell-based format | Scientific Literature | |
| 11. | ALA5139773 | F | Antiproliferative activity against human THLE-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 6 | ALA5137027 | cell-based format | Scientific Literature | |
| 12. | ALA5139774 | F | Antiproliferative activity against mouse BaF3 cells harboring TRKA G595R mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Mus musculus | 9 | ALA5137027 | cell-based format | Scientific Literature | |
| 13. | ALA5139873 | F | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 6 | ALA5137027 | cell-based format | Scientific Literature |
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