# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5164252 | B | Inhibition of NLRP3 inflammasome oligomerization in LPS-primed mouse BMDM cells assessed as prevention of ASC specks formation at 1 uM pretreated for 15 mins followed by MSU stimulation for 30 mins by DAPI staining based confocal microscopic analysis | Mus musculus | 1 | ALA5154853 | cell-based format | Scientific Literature | |
2. | ALA5164253 | B | Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta level at 1 uM pre-treated for 15 mins followed by ATP stimulation for 30 mins by ELISA relative to control | Mus musculus | 15 | ALA5154853 | cell-based format | Scientific Literature | |
3. | ALA5164254 | B | Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta level at 3 uM pre-treated for 15 mins followed by ATP stimulation for 30 mins by ELISA relative to control | Mus musculus | 15 | ALA5154853 | cell-based format | Scientific Literature | |
4. | ALA5164255 | B | Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta level at 10 uM pre-treated for 15 mins followed by ATP stimulation for 30 mins by ELISA relative to control | Mus musculus | 15 | ALA5154853 | cell-based format | Scientific Literature | |
5. | ALA5164256 | T | Cytotoxicity against mouse AML12 cells assessed as reduction in cell viability at 0.01 to 30 uM measured after 24 hrs by MTT assay | Mus musculus | 2 | ALA5154853 | cell-based format | Scientific Literature | |
6. | ALA5164257 | T | Cytotoxicity against mouse J774.A1 cells assessed as reduction in cell viability at 10 uM measured after 24 hrs by MTT assay relative to control | Mus musculus | 2 | ALA5154853 | cell-based format | Scientific Literature | |
7. | ALA5164258 | T | Cytotoxicity against mouse J774.A1 cells assessed as reduction in cell viability at 30 uM measured after 24 hrs by MTT assay relative to control | Mus musculus | 2 | ALA5154853 | cell-based format | Scientific Literature | |
8. | ALA5164259 | T | Cytotoxicity against mouse J774.A1 cells assessed as reduction in cell viability at 0.01 to 3 uM measured after 24 hrs by MTT assay | Mus musculus | 2 | ALA5154853 | cell-based format | Scientific Literature | |
9. | ALA5164260 | B | Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in ATP induced IL-1beta release pretreated for 15 mins followed by ATP stimulation for 30 mins by ELISA | Mus musculus | 2 | ALA5154853 | cell-based format | Scientific Literature | |
10. | ALA5164261 | B | Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in MSU induced IL-1beta release at 1 uM pretreated for 15 mins followed by MSU addition for 30 mins by ELISA | Mus musculus | 2 | ALA5154853 | cell-based format | Scientific Literature | |
11. | ALA5164262 | B | Inhibition of NLRP3 inflammasome oligomerization in LPS-primed mouse BMDM cells assessed as prevention of ASC specks formation at 1 uM pretreated for 15 mins followed by ATP stimulation for 30 mins by DAPI staining based confocal microscopic analysis | Mus musculus | 1 | ALA5154853 | cell-based format | Scientific Literature | |
12. | ALA5164263 | F | Inhibition of ATP-induced TNF-alpha production in LPS-primed mouse BMDM cells at 1 uM pretreated for 15 mins followed by ATP stimulation for 30 mins | Mus musculus | 1 | ALA5154853 | cell-based format | Scientific Literature | |
13. | ALA5164264 | B | Inhibition of AIM2 inflammasome activation in LPS-treated mouse BMDM assessed as reduction in poly-(dA:dT) induced IL-1beta release at 1 uM pretreated for 15 mins followed by poly-(dA:dT) addition and further incubated for 16 hrs by ELISA | Mus musculus | 1 | ALA5154853 | cell-based format | Scientific Literature | |
14. | ALA5164265 | B | Inhibition of NLRC4 inflammasome activation in LPS-treated mouse BMDM assessed as reduction in flagellin induced IL-1beta release at 1 uM pretreated for 15 mins followed by flagellin addition and further incubated for 16 hrs by ELISA | Mus musculus | 1 | ALA5154853 | cell-based format | Scientific Literature | |
15. | ALA5164266 | F | Antiinflammatory activity in MSU-induced acute gout arthritis in wild type male C57BL/6J mouse model assessed as decrease in paw inflammation at 3 to 10 mg/kg, ip measured after 24 hrs | Mus musculus | 1 | ALA5154853 | organism-based format | Scientific Literature | |
16. | ALA5164268 | F | Antiinflammatory activity in MSU-induced acute gout arthritis in wild type male C57BL/6J mouse model assessed as decrease in paw inflammation at 3 mg/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA5154853 | organism-based format | Scientific Literature | |
17. | ALA5164269 | F | Antiinflammatory activity in MSU-induced acute gout arthritis in wild type female C57BL/6J mouse model assessed as decrease in paw inflammation at 3 mg/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA5154853 | organism-based format | Scientific Literature | |
18. | ALA5164270 | F | Antiinflammatory activity in MSU-induced acute gout arthritis in wild type male C57BL/6J mouse model assessed as decrease in paw inflammation at 10 mg/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA5154853 | organism-based format | Scientific Literature | |
19. | ALA5164271 | F | Antiinflammatory activity in MSU-induced acute gout arthritis in wild type female C57BL/6J mouse model assessed as decrease in paw inflammation at 10 mg/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA5154853 | organism-based format | Scientific Literature | |
20. | ALA5164273 | F | Antiinflammatory activity in MSU-induced acute gout arthritis in NLRP3 knockout male C57BL/6J mouse model assessed as reduction in paw inflammation at 3 to 10 mg/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA5154853 | organism-based format | Scientific Literature |