| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5168829 | B | Inhibition of recombinant human MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as a substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluroscence based assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 2. | ALA5168830 | B | Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 3. | ALA5168831 | B | Inhibition of recombinant human MMP13 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 4. | ALA5168832 | B | Selectivity ratio of IC50 for recombinant human MMP12 to IC50 for recombinant human MMP2 | Homo sapiens | 28 | assay format | Scientific Literature | ||
| 5. | ALA5168833 | B | Selectivity ratio of IC50 for recombinant human MMP13 to IC50 for recombinant human MMP2 | Homo sapiens | 28 | protein format | Scientific Literature | ||
| 6. | ALA5168835 | A | Metabolic stability in rat hepatocytes assessed as parent compound remaining incubated for 1 hr by LC-MS/MS | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA5168836 | P | Lipophilicity, log D of the compound at pH 7.4 by HPLC analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5168842 | B | Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 9. | ALA5168843 | B | Inhibition of recombinant human MMP3 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 10. | ALA5168844 | B | Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 11. | ALA5168845 | B | Inhibition of recombinant human MMP8 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 12. | ALA5168846 | B | Inhibition of recombinant human MMP9 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 13. | ALA5168847 | B | Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 14. | ALA5168863 | B | Selectivity ratio of IC50 for recombinant human MMP1 to IC50 for recombinant human MMP2 | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 15. | ALA5168864 | B | Selectivity ratio of IC50 for recombinant human MMP3 to IC50 for recombinant human MMP2 | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 16. | ALA5168865 | B | Selectivity ratio of IC50 for recombinant human MMP7 to IC50 for recombinant human MMP2 | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 17. | ALA5168866 | B | Selectivity ratio of IC50 for recombinant human MMP8 to IC50 for recombinant human MMP2 | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 18. | ALA5168867 | B | Selectivity ratio of IC50 for recombinant human MMP9 to IC50 for recombinant human MMP2 | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 19. | ALA5168868 | B | Selectivity ratio of IC50 for recombinant human MMP14 to IC50 for recombinant human MMP2 | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 20. | ALA5168869 | A | Clearance in fasted Sprague-Dawley rat at 0.4 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature |
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