| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5165027 | B | Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition and incubated for 60 mins by microplate reader assay | Homo sapiens | 47 | ALA5154871 | single protein format | Scientific Literature | |
| 2. | ALA5165028 | B | Inhibition of Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 1 hr followed by substrate addition and incubated for 60 mins by microplate reader assay | Homo sapiens | 45 | ALA5154871 | cell-based format | Scientific Literature | |
| 3. | ALA5165029 | B | Inhibition of Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 1 hr followed by substrate addition and incubated for 60 mins by microplate reader assay | Homo sapiens | 45 | ALA5154871 | cell-based format | Scientific Literature | |
| 4. | ALA5165030 | B | Inhibition of human recombinant Cathepsin L using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition and incubated for 30 mins by microplate reader assay | Homo sapiens | 3 | ALA5154871 | single protein format | Scientific Literature | |
| 5. | ALA5165031 | B | Inhibition of human recombinant Cathepsin B using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition and incubated for 30 mins by microplate reader assay | Homo sapiens | 3 | ALA5154871 | single protein format | Scientific Literature | |
| 6. | ALA5165032 | B | Inhibition of human recombinant Cathepsin S using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed by substrate addition and incubated for 30 mins by microplate reader assay | Homo sapiens | 3 | ALA5154871 | single protein format | Scientific Literature | |
| 7. | ALA5165033 | B | Inhibition of human Cathepsin K using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed by substrate addition and incubated for 30 mins by microplate reader assay | Homo sapiens | 3 | ALA5154871 | single protein format | Scientific Literature | |
| 8. | ALA5165034 | B | Binding affinity to Cathepsin C in human U-937 cells assessed as increase in thermal stability at 10 uM measured from 46 to 52 degC after 4 hrs by cellular thermal shift assay | Homo sapiens | 1 | ALA5154871 | cell-based format | Scientific Literature | |
| 9. | ALA5165035 | T | Acute toxicity in ICR mouse assessed as body weight loss at 1500 mg/kg, po administered as single dose and measured for 7 days | Mus musculus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 10. | ALA5165036 | T | Acute toxicity in ICR mouse assessed as pathological changes of kidney at 1500 mg/kg, po administered as single dose measured after 7 days by H and E staining based assay | Mus musculus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 11. | ALA5165037 | T | Acute toxicity in ICR mouse assessed as pathological changes of liver at 1500 mg/kg, po administered as single dose measured after 7 days by H and E staining based assay | Mus musculus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 12. | ALA5165038 | T | Acute toxicity in ICR mouse assessed as pathological changes of lungs at 1500 mg/kg, po administered as single dose measured after 7 days by H and E staining based assay | Mus musculus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 13. | ALA5165039 | T | Acute toxicity in ICR mouse assessed as pathological changes of heart at 1500 mg/kg, po administered as single dose measured after 7 days by H and E staining based assay | Mus musculus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 14. | ALA5165040 | T | Acute toxicity in ICR mouse assessed as pathological changes of spleen at 1500 mg/kg, po administered as single dose measured after 7 days by H and E staining based assay | Mus musculus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 15. | ALA5165041 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 16. | ALA5165042 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 17. | ALA5165043 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 18. | ALA5165044 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 19. | ALA5165045 | A | MRT in Sprague-Dawley rat at 10 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5154871 | organism-based format | Scientific Literature | |
| 20. | ALA5165046 | A | MRT in Sprague-Dawley rat at 2 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5154871 | organism-based format | Scientific Literature |
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