| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5157720 | B | Inhibition of human full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell using fluorogenic HDAC class 2a substrate measured after 30 mins by fluorimetry | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA5157721 | T | Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using fluorogenic HDAC substrate 3 measured after 30 mins by fluorimetry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA5157722 | B | Inhibition of C-terminal His-tagged human HDAC3 (1 to 428 residues)/N-terminal GST tagged human NCOR2 (395 to 489) expressed in baculovirus infected Sf9 insect cells using fluorogenic HDAC substrate measured after 30 mins by fluorimetry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA5157723 | B | Inhibition of recombinant human full-length C-terminal Flag-His6-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using fluorogenic HDAC substrate measured after 30 mins by fluorimetry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA5157724 | B | Inhibition of HDAC in human HeLa cell nuclear extracts using color de Lys as substrate measured after 30 mins by colorimetric assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 6. | ALA5157727 | T | Inhibition of recombinant human N-terminal GST-fused/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 insect cells using fluorogenic HDAC class 2a substrate measured after 30 mins by fluorimetry | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA5157734 | F | Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 8. | ALA5157735 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 9. | ALA5157736 | F | Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 10. | ALA5157737 | F | Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 11. | ALA5157738 | F | Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 12. | ALA5157739 | F | Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 13. | ALA5157740 | F | Potency index, ratio of MS-275 IC50 to test compound IC50 for antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA5157741 | F | Potency index, ratio of SAHA IC50 to test compound IC50 for antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA5157742 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H3K9 at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA5157743 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H4K5 at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA5157746 | T | Inhibition of HDAC6 in human HCT-116 cells assessed as increase in alpha-tubulin acetylation at 5 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA5157749 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H3K9 at 5 uM treated for 48 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA5157750 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H4K5 at 5 uM treated for 48 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA5157751 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HCT-116 cells assessed as increase in accumulation of acetylated H3K9 at 5 uM preincubated for 6 hrs followed by compound washout and measured up to 48 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!