# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5122517 | Functional | Cytotoxicity against human HCC1937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 11 | ALA5120815 | cell-based format | Scientific Literature | |
2. | ALA5122518 | Functional | Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 11 | ALA5120815 | cell-based format | Scientific Literature | |
3. | ALA5122519 | Functional | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 11 | ALA5120815 | cell-based format | Scientific Literature | |
4. | ALA5122520 | Functional | Cytotoxicity against human MCF7 cells harbouring wild type BRCA1/2 assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 11 | ALA5120815 | cell-based format | Scientific Literature | |
5. | ALA5122521 | Functional | Cytotoxicity against human MX1 cells harbouring BRCA1 mutant assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 11 | ALA5120815 | cell-based format | Scientific Literature | |
6. | ALA5122522 | Functional | Cytotoxicity against human SK-BR-3 cells harbouring wild type BRCA1/2 assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 11 | ALA5120815 | cell-based format | Scientific Literature | |
7. | ALA5122523 | Binding | Inhibition of PARP-1 (unknown origin) at 0.1 uM preincubated for 10 mins followed by PARP cocktail addition and measured after 60 mins by colorimetric assay relative to control | Homo sapiens | 1 | ALA5120815 | single protein format | Scientific Literature | |
8. | ALA5122524 | Binding | Inhibition of human EGFR in human HCC1937 cells at 10 uM incubated for 48 hrs by ELISA | Homo sapiens | 2 | ALA5120815 | cell-based format | Scientific Literature | |
9. | ALA5122525 | Binding | Inhibition of human EGFR in human HCC1937 cells assessed as reduction in EGFR level at 10 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5120815 | cell-based format | Scientific Literature | |
10. | ALA5122526 | Binding | Inhibition of human EGFR in human HCC1937 cells assessed as reduction in phosphorylated EGFR level at 10 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5120815 | cell-based format | Scientific Literature | |
11. | ALA5122527 | Functional | Cytotoxicity against human MCF7 cells harbouring wild type BRCA1/2 assessed as inhibition of cell growth at 25 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 8 | ALA5120815 | cell-based format | Scientific Literature | |
12. | ALA5122530 | Functional | Potentiation of adriamycin-induced cytotoxicity in human MCF7 cells harbouring wild type BRCA1/2 assessed as inhibition of cell growth at 25 uM incubated for 48 hrs in presence of 0.8 uM adriamycin by MTT assay relative to control | Homo sapiens | 8 | ALA5120815 | cell-based format | Scientific Literature | |
13. | ALA5122533 | Functional | Synergistic cytotoxicity against human MCF7 cells harbouring wild type BRCA1/2 assessed as combination index at 25 uM incubated for 48 hrs in presence of 0.8 uM adriamycin by MTT assay | Homo sapiens | 8 | ALA5120815 | cell-based format | Scientific Literature | |
14. | ALA5122536 | Binding | Inhibition of PARP-1 in human MCF7 cells assessed as inhibition of PARylation by measuring reduction in PARP protein expression at 1 uM pretreated with adriamycin followed by compound addition and measured after 48 hrs by Western bot analysis | Homo sapiens | 1 | ALA5120815 | cell-based format | Scientific Literature |