# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5112265 | B | Competitive binding affinity to recombinant Pseudomonas aeruginosa PA14 LecB expressed in Escherichia coli BL21(DE3) incubated for 4 to 8 hrs by fluorescent polarization assay | Pseudomonas aeruginosa | 5 | assay format | Scientific Literature | ||
2. | ALA5112266 | B | Competitive binding affinity to recombinant Pseudomonas aeruginosa PAO1 LecB expressed in Escherichia coli BL21(DE3) incubated for 4 to 8 hrs by fluorescent polarization assay | Pseudomonas aeruginosa | 5 | assay format | Scientific Literature | ||
3. | ALA5112268 | A | Prodrug activation assessed as LasB-mediated drug release in Pseudomonas aeruginosa PA14 cell supernatant in presence of human blood plasma and measured for 3 hrs by HPLC-MS analysis | Pseudomonas aeruginosa | 6 | cell-free format | Scientific Literature | ||
4. | ALA5112269 | A | Stability of compound in human blood plasma spiked with Pseudomonas aeruginosa PA14 matrix assessed as hydrolysis of prodrug and measured upto 3 hrs by HPLC-MS/MS analysis | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
5. | ALA5112270 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 10 mins in PBS buffer followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
6. | ALA5112271 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 3 hrs in PBS buffer followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
7. | ALA5112272 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 10 mins in matrix containing human blood plasma spiked with Pseudomonas aeruginosa cell culture supernatant in PBS buffer followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
8. | ALA5112273 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 3 hrs in matrix containing 50% human blood plasma and 10% Pseudomonas aeruginosa cell culture supernatant in PBS followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
9. | ALA5112274 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 3 hrs in matrix containing human blood plasma spiked with Pseudomonas aeruginosa cell culture supernatant in PBS buffer followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
10. | ALA5112275 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 3 hrs in matrix containing Pseudomonas aeruginosa cell culture supernatant in PBS buffer followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
11. | ALA5112276 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 10 mins in matrix containing human blood plasma spiked with fresh LB medium in PBS followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
12. | ALA5112277 | F | Antibacterial activity against Pseudomonas aeruginosa PA14 assessed inhibition of bacterial growth preincubated for 3 hrs in matrix containing human blood plasma spiked with fresh LB medium in PBS followed by overnight grown bacterial culture addition incubated for 18 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 7 | organism-based format | Scientific Literature | ||
13. | ALA5112279 | A | Metabolic stability in mouse liver microsomes assessed as half life at 100 uM preincubated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Mus musculus | 3 | microsome format | Scientific Literature | ||
14. | ALA5112280 | A | Metabolic stability in human liver microsomes assessed as half life at 100 uM preincubated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
15. | ALA5112281 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance measured per mg protein at 100 uM preincubated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Mus musculus | 3 | microsome format | Scientific Literature | ||
16. | ALA5112282 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance measured per mg protein at 100 uM preincubated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
17. | ALA5112283 | A | Stability in mouse plasma assessed as half life at 1 uM and measured upto 240 mins by HPLC-MS/MS analysis | Mus musculus | 3 | cell-free format | Scientific Literature | ||
18. | ALA5112284 | A | Stability in human plasma assessed as half life at 1 uM and measured upto 240 mins by HPLC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
19. | ALA5112285 | A | Protein binding in CD-1 mouse plasma at 1 uM incubated for incubated for 2 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | cell-free format | Scientific Literature | ||
20. | ALA5112286 | A | Protein binding in human plasma at 1 uM incubated for incubated for 2 hrs by HPLC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature |