# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5149233 | Binding | Inhibition of JAK3 (unknown origin) at 300 uM measured after 40 mins in presence of ATP by luminescence assay relative to control | Homo sapiens | 2 | ALA5143731 | single protein format | Scientific Literature | |
2. | ALA5149234 | Physicochemical | Half life of the compound in buffer | 23 | ALA5143731 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5149235 | Physicochemical | Half life of the compound in DMSO | 23 | ALA5143731 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5149236 | Physicochemical | Half life of the compound in GSH | 21 | ALA5143731 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA5149237 | Binding | Inhibition of human FBPase expressed Escherichia coli BL21 in by malachite green dye based spectrophotometry | Homo sapiens | 9 | ALA5143731 | single protein format | Scientific Literature | |
6. | ALA5149238 | Binding | Inhibition of EGFR (unknown origin) at 300 uM measured after 40 mins in presence of ATP by luminescence assay relative to control | Homo sapiens | 2 | ALA5143731 | single protein format | Scientific Literature | |
7. | ALA5149239 | Binding | Selectivity ratio of IC50 for human FBPase to IC50 for recombinant ALDOA (unknown origin) | Homo sapiens | 6 | ALA5143731 | assay format | Scientific Literature | |
8. | ALA5149240 | Binding | Selectivity ratio of IC50 for human FBPase to IC50 for recombinant ALDOB (unknown origin) | Homo sapiens | 6 | ALA5143731 | assay format | Scientific Literature | |
9. | ALA5149241 | Binding | Selectivity ratio of IC50 for human FBPase to IC50 for recombinant ALDOC (unknown origin) | Homo sapiens | 6 | ALA5143731 | assay format | Scientific Literature | |
10. | ALA5149242 | Binding | Selectivity ratio of IC50 for human FBPase to IC50 for human GAPDH | Homo sapiens | 6 | ALA5143731 | assay format | Scientific Literature | |
11. | ALA5149243 | Binding | Inhibition of BTK (unknown origin) at 300 uM measured after 40 mins in presence of ATP by luminescence assay relative to control | Homo sapiens | 2 | ALA5143731 | single protein format | Scientific Literature | |
12. | ALA5149246 | Functional | Hypoglycemic activity in ICR mouse assessed as glucose lowering effect at 30 mg/kg, ip measured after 2 to 6 hrs | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature | |
13. | ALA5149248 | Functional | Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as glucose lowering effect at 10 to 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature | |
14. | ALA5149249 | Functional | Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 6 hrs) at 10 mg/kg, ip measured after 6 hrs | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature | |
15. | ALA5149250 | Functional | Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 6 hrs) at 30 mg/kg, ip measured after 6 hrs | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature | |
16. | ALA5149251 | Functional | Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 2 hrs) at 10 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature | |
17. | ALA5149252 | Functional | Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 2 hrs) at 30 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature | |
18. | ALA5149253 | Binding | Inhibition of human FBPase in ICR mouse serum starved primary hepatocytes assessed as glucose lowering effect | Homo sapiens | 1 | ALA5143731 | cell-based format | Scientific Literature | |
19. | ALA5149254 | Toxicity | Cytotoxicity in ICR mouse serum starved primary hepatocytes assessed as reduction in cell viability at 50 to 300 uM | Mus musculus | 1 | ALA5143731 | cell-based format | Scientific Literature | |
20. | ALA5149256 | Functional | Hypoglycemic activity in ICR mouse assessed as improvement in glucose tolerance at 10 to 30 mg/kg, ip administered after oral glucose at 2 g/kg and measured after 0.25 hr by OGTT | Mus musculus | 1 | ALA5143731 | organism-based format | Scientific Literature |