# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5123181 | B | Displacement of [3H]ifenprodil from recombinant human GluN1A/GluN2B expressed in mouse L-M(TK-) cell membranes after 120 mins by microbeta scintillation counting method | Homo sapiens | 30 | cell membrane format | Scientific Literature | ||
2. | ALA5123182 | B | Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes measured after 120 mins by scintillation counting method | Cavia porcellus | 33 | cell membrane format | Scientific Literature | ||
3. | ALA5123183 | B | Displacement of [3H]-DTG from sigma 2 receptor in rat liver membrane measured after 120 mins by microbeta counting analysis | Rattus norvegicus | 32 | cell membrane format | Scientific Literature | ||
4. | ALA5123184 | B | Antagonist activity at GluN1a/GluN2B NMDA receptor (unknown origin) expressed in Xenopus oocytes assessed as inhibition of glycine and (S)-glutamate-induced ion channel activation at 1 uM at -70 mV holding potential by two-electrode voltage clamp method relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
5. | ALA5157898 | A | Drug metabolism in mouse liver microsomes assessed as compound oxidization incubated for 90 mins in presence of NAPDH | Mus musculus | 1 | microsome format | Scientific Literature | ||
6. | ALA5157899 | B | Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane by competitive radioligand receptor binding assay | Cavia porcellus | 8 | cell membrane format | Scientific Literature | ||
7. | ALA5157900 | B | Displacement of [3H]di-O-tolylguanidine from sigma 2 receptor in rat liver membrane by competitive radioligand receptor binding assay | Rattus norvegicus | 7 | cell membrane format | Scientific Literature | ||
8. | ALA5157901 | P | Distribution coefficient between n-Octanol and aqueous buffer, logD of the compound in pH 7.4 buffer by LC/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA5157902 | A | Protein binding in human serum albumin by HPAC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
10. | ALA5157903 | F | Antiallodynic activity in capsaicin-induced mechanical allodynia CD1 mouse model assessed as reduction in mechanical allodynia administered subcutaneously preincubated for 30 min followed by capsaicin injection and measured after 15 mins by Von Frey filament assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA5157904 | F | Antiallodynic activity in capsaicin-induced mechanical allodynia CD1 mouse model assessed as reduction in mechanical allodynia at 32 mg/kg, sc preincubated with PRE-084 for 5 min followed by incubation with compound for 30 min further stimulated with capsaicin and measured after 15 mins by Von Frey filament assay | Mus musculus | 1 | organism-based format | Scientific Literature |