# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5157021 | A | Cmax in CD-1 mouse plasma at 0.5 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA5154686 | organism-based format | Scientific Literature | |
2. | ALA5157022 | B | Inhibition of full length wild type LRRK2 (unknown origin) by LRRKtide Adapta assay | Homo sapiens | 52 | ALA5154686 | single protein format | Scientific Literature | |
3. | ALA5157023 | B | Inhibition of full length LRRK2 G2019S mutant (unknown origin) by LRRKtide Adapta assay | Homo sapiens | 52 | ALA5154686 | single protein format | Scientific Literature | |
4. | ALA5157024 | B | Selectivity ratio of IC50 for wild type LRRK2 (unknown origin) to IC50 for LRRK2 G2019S mutant (unknown origin) | Homo sapiens | 52 | ALA5154686 | assay format | Scientific Literature | |
5. | ALA5157025 | B | Inhibition of wild type pcDNA5FRT-TO-GFP fused - LRRK2 (unknown origin) transfected in HEK293 cells incubated for 24 hrs by ELISA | Homo sapiens | 52 | ALA5154686 | cell-based format | Scientific Literature | |
6. | ALA5157026 | B | Inhibition of pcDNA5FRT-TO-GFP fused - LRRK2 G2019S mutant (unknown origin) transfected in HEK293 cells incubated for 24 hrs by ELISA | Homo sapiens | 52 | ALA5154686 | cell-based format | Scientific Literature | |
7. | ALA5157027 | B | Inhibition of pcDNA5FRT-TO-GFP fused - LRRK2 (unknown origin) transfected in HEK293 cells assessed as remaining activity at 30 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 52 | ALA5154686 | cell-based format | Scientific Literature | |
8. | ALA5157028 | B | Selectivity ratio of IC50 for wild type pcDNA5FRT-TO-GFP fused - LRRK2 (unknown origin) to IC50 for pcDNA5FRT-TO-GFP fused - LRRK2 G2019S mutant transfected in HEK293 cells | Homo sapiens | 52 | ALA5154686 | cell-based format | Scientific Literature | |
9. | ALA5157032 | B | Inhibition of wild type LRRK2 (unknown origin) transfected in HEK293 cells upto 1000 nM incubated for 24 hrs by immunoblotting method | Homo sapiens | 4 | ALA5154686 | cell-based format | Scientific Literature | |
10. | ALA5157033 | B | Inhibition of LRRK2 G2019S/A2016T double mutant (unknown origin) transfected in HEK293 cells upto 1000 nM incubated for 24 hrs by immunoblotting method | Homo sapiens | 4 | ALA5154686 | cell-based format | Scientific Literature | |
11. | ALA5157038 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells by LC-MS/MS analysis | Homo sapiens | 10 | ALA5154686 | cell-based format | Scientific Literature | |
12. | ALA5157039 | A | Permeability across basolateral to apical side in human Caco-2 cells by LC-MS/MS analysis | Homo sapiens | 10 | ALA5154686 | cell-based format | Scientific Literature | |
13. | ALA5157040 | A | Efflux ratio of permeability across basolateral to apical over apical to basolateral side in Caco-2 cells | Homo sapiens | 10 | ALA5154686 | cell-based format | Scientific Literature | |
14. | ALA5157041 | A | Metabolic stability in mouse liver microsomes assessed as half life | Mus musculus | 10 | ALA5154686 | microsome format | Scientific Literature | |
15. | ALA5157042 | A | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 10 | ALA5154686 | microsome format | Scientific Literature | |
16. | ALA5157043 | A | AUC infinity in CD-1 mouse plasma at 0.5 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA5154686 | organism-based format | Scientific Literature | |
17. | ALA5157044 | A | AUC infinity in CD-1 mouse plasma at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA5154686 | organism-based format | Scientific Literature | |
18. | ALA5157047 | A | Cmax in CD-1 mouse plasma at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA5154686 | organism-based format | Scientific Literature | |
19. | ALA5157050 | A | Tmax in CD-1 mouse plasma at 0.5 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA5154686 | organism-based format | Scientific Literature | |
20. | ALA5157051 | A | Tmax in CD-1 mouse plasma at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA5154686 | organism-based format | Scientific Literature |