# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5168252 | F | Induction of apoptosis in rat HSC-T6 cells assessed as necrotic cells at 40 nM pretreated with TGFbeta-1 for 1 day followed by compound addition and measured after 24 hrs by flow cytometry (Rvb = 0.56 %) | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
2. | ALA5168253 | F | Induction of mitochondrial membrane potential changes in human Huh-7 cells assessed as decrease in TMRE positive cells at 80 nM incubated for 24 hrs by TMRE staining based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA5168254 | F | Induction of apoptosis in rat HSC-T6 cells assessed as early apoptotic cells at 40 nM pretreated with TGFbeta-1 for 1 day followed by compound addition and measured after 24 hrs by flow cytometry (Rvb = 0.17 %) | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
4. | ALA5168255 | F | Antiproliferative activity against human HepG2 cells treated for 72 hrs by MTT assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
5. | ALA5168256 | F | Antiproliferative activity against human Huh-7 cells treated for 72 hrs by MTT assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
6. | ALA5168257 | F | Antiproliferative activity against human SK-HEP1 cells treated for 72 hrs by MTT assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
7. | ALA5168258 | F | Antiproliferative activity against human HCCLM9 cells treated for 72 hrs by MTT assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
8. | ALA5168259 | T | Antiproliferative activity against human L02 cells treated for 72 hrs by MTT assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
9. | ALA5168260 | B | Inhibition of Top1 (unknown origin) assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 50 uM incubated for 25 mins by ethidium bromide staining based agarose gel electrophoresis analysis relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
10. | ALA5168261 | B | Inhibition of Top1 (unknown origin) assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 12.5 uM incubated for 25 mins by ethidium bromide staining based agarose gel electrophoresis analysis relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
11. | ALA5168262 | B | Inhibition of human Top2-alpha expressed in baculovirus assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 100 uM incubated for 30 mins in presence of ATP by ethidium bromide staining based agarose gel electrophoresis analysis relative to control | Homo sapiens | 9 | assay format | Scientific Literature | ||
12. | ALA5168264 | F | Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell viability by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA5168265 | F | Antiproliferative activity against human SK-Hep1 cells assessed as inhibition of cell viability by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA5168266 | F | Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell viability treated for 24 to 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA5168267 | F | Antiproliferative activity against human SK-Hep1 cells assessed as inhibition of cell viability treated for 24 to 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA5168270 | F | Antiproliferative activity against human SK-Hep1 cells assessed as inhibition of cell viability at less than 0.068 uM treated for 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA5168271 | F | Antiproliferative activity against human SK-Hep1 cells assessed as inhibition of cell viability at less than 0.227 uM treated for 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA5168272 | F | Inhibition of clonogenicity in human HCC cells assessed as decrease in number of colonies at 3 to 18 nM incubated for 1 to 2 weeks by optical microscopy analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA5168273 | F | Inhibition of cell proliferation of human HCC cells treated for 24 hrs by EdU staining based fluorescence microscopy assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA5168274 | F | Induction of cell cycle arrest in human SK-Hep1 cells assessed as accumulation at S phase at 80 nM treated for 24 hrs by PI staining based flow cytometry (Rvb = 24.98 %) | Homo sapiens | 4 | cell-based format | Scientific Literature |