# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5126259 | F | Anti-osteoporosis activity C57/BL6 mouse bone marrow macrophage cells assessed as inhibition of RANKL-induced osteoclastogenesis at 1 uM measured after 5 to 6 days in presence of M-CSF and RNKL by TRAP staining microscopic analysis | Mus musculus | 40 | ALA5120967 | cell-based format | Scientific Literature | |
2. | ALA5126260 | F | Anti-osteoporosis activity C57/BL6 mouse bone marrow macrophage cells assessed as inhibition of RANKL-induced osteoclastogenesis at 0.1 uM measured after 5 to 6 days in presence of M-CSF and RNKL by TRAP staining microscopic analysis | Mus musculus | 22 | ALA5120967 | cell-based format | Scientific Literature | |
3. | ALA5126261 | T | Cytotoxicity against C57/BL6 mouse bone marrow macrophage cells assessed as reduction in cell viability at 10 uM incubated for 3 days by CCK8 assay | Mus musculus | 43 | ALA5120967 | cell-based format | Scientific Literature | |
4. | ALA5126262 | F | Anti-osteoporosis activity C57/BL6 mouse bone marrow macrophage cells assessed as inhibition of RANKL-induced osteoclastogenesis and measured after 5 to 6 days in presence of M-CSF by TRAP staining based assay | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
5. | ALA5126263 | T | Cytotoxicity against C57/BL6 mouse bone marrow macrophage cells at 5 uM measured after 3 days in presence of M-CSF by CCK-8 assay | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
6. | ALA5126264 | F | Anti-osteoporosis activity C57/BL6 mouse bone marrow macrophage cells assessed as inhibition of RANKL-induced F-actin levels upto 5 uM measured after 5 to 6 days in presence of M-CSF by DAPI staining analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
7. | ALA5126265 | F | Anti-osteoporosis activity C57/BL6 mouse bone marrow macrophage cells assessed as inhibition of RANKL-induced F-actin size upto 5 uM measured after 5 to 6 days in presence of M-CSF by DAPI staining analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
8. | ALA5126266 | F | Anti-osteoporosis activity C57/BL6 mouse bone marrow macrophage cells assessed as inhibition of RANKL-induced osteoclastogenesis measured after 5 to 6 days in presence of M-CSF by DAPI staining analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
9. | ALA5126267 | F | Inhibition of RANKL-induced TRAP in mRNA expression in C57/BL6 mouse bone marrow macrophage cells upto 5 uM measured after 3 days by qRT-PCR analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
10. | ALA5126268 | F | Inhibition of RANKL-induced Cathepsin K in mRNA expression in C57/BL6 mouse bone marrow macrophage cells upto 5 uM measured after 3 days by qRT-PCR analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
11. | ALA5126269 | F | Inhibition of RANKL-induced c-fos in mRNA expression in C57/BL6 mouse bone marrow macrophage cells upto 5 uM measured after 3 days by qRT-PCR analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
12. | ALA5126270 | F | Inhibition of RANKL-induced NFATc1 in mRNA expression in C57/BL6 mouse bone marrow macrophage cells upto 5 uM measured after 3 days by qRT-PCR analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
13. | ALA5126271 | B | Binding affinity to human RANKL assessed as dissociation constant by surface plasmon resonance method | Homo sapiens | 1 | ALA5120967 | single protein format | Scientific Literature | |
14. | ALA5126272 | F | Inhibition of RANKL-induced c-FOS protein expression in C57/BL6 mouse bone marrow macrophage cells upto 10 uM measured for 3 days in presence of M-CSF and RANKL by Western blot analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
15. | ALA5126273 | F | Inhibition of RANKL-induced NFATC1 protein expression in C57/BL6 mouse bone marrow macrophage cells upto 10 uM measured for 3 days in presence of M-CSF and RANKL by Western blot analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
16. | ALA5126274 | F | Induction of bone regeneration in C57/BL6 mouse bone marrow macrophage cells assessed as decrease in bone restoration at 1 to 5 uM by toluidine blue staining based microscopic analysis | Mus musculus | 1 | ALA5120967 | cell-based format | Scientific Literature | |
17. | ALA5126275 | A | AUC(0 to t) in OVX-induced C57/BL6 mouse model at 3 mg/kg, iv | Mus musculus | 2 | ALA5120967 | organism-based format | Scientific Literature | |
18. | ALA5126276 | A | Half life in OVX-induced C57/BL6 mouse model at 3 mg/kg, iv | Mus musculus | 2 | ALA5120967 | organism-based format | Scientific Literature | |
19. | ALA5126277 | A | Clearance in OVX-induced C57/BL6 mouse model at 3 mg/kg, iv | Mus musculus | 2 | ALA5120967 | organism-based format | Scientific Literature | |
20. | ALA5126278 | A | Oral bioavailability in OVX-induced C57/BL6 mouse model | Mus musculus | 2 | ALA5120967 | organism-based format | Scientific Literature |