| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5166005 | B | Inhibition of eGFP-tagged rat GluN1/GluN2A transfected in human tsA201 cells assessed as blockade of glycine/NMDA-induced current at 10 uM treated for 40 secs measured at -60 mV holding potential after returning from +60 mV application for 5 secs by whole-cell patch-clamp method relative to control | Rattus norvegicus | 4 | ALA5154888 | cell-based format | Scientific Literature | |
| 2. | ALA5166007 | B | Inhibition of eGFP-tagged rat GluN1/GluN2A transfected in human tsA201 cells assessed as weighted time constant for blockade of glycine/NMDA-induced current at 10 uM at 1 sec by whole-cell patch-clamp method | Rattus norvegicus | 4 | ALA5154888 | cell-based format | Scientific Literature | |
| 3. | ALA5166008 | B | Inhibition of eGFP-tagged rat GluN1/GluN2A transfected in human tsA201 cells assessed as recovery of glycine/NMDA-induced current at 10 uM treated for 40 secs followed by application of +60 mV holding potential for 5 secs measured after 40 secs of compound removal by whole-cell patch-clamp method relative to control | Rattus norvegicus | 3 | ALA5154888 | cell-based format | Scientific Literature | |
| 4. | ALA5166010 | B | Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV holding potential applied for 10 secs by whole-cell patch-clamp method | Rattus norvegicus | 4 | ALA5154888 | cell-based format | Scientific Literature | |
| 5. | ALA5166011 | B | Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV holding potential applied for 10 secs in presence of Mg2+ by whole-cell patch-clamp method | Rattus norvegicus | 1 | ALA5154888 | cell-based format | Scientific Literature | |
| 6. | ALA5166012 | A | Microsomal stability in human liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by UPLC-MS/MS analysis | Homo sapiens | 1 | ALA5154888 | microsome format | Scientific Literature | |
| 7. | ALA5166013 | A | Microsomal stability in mouse liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by UPLC-MS/MS analysis | Mus musculus | 1 | ALA5154888 | microsome format | Scientific Literature | |
| 8. | ALA5166014 | A | Inhibition of human recombinant CYP1A2 at 10 uM using 3-cyano-7-ethoxycoumarin as substrate preincubated for 5 mins followed by enzyme/substrate mix addition measured by fluoroscence plate reader assay | Homo sapiens | 1 | ALA5154888 | single protein format | Scientific Literature | |
| 9. | ALA5166015 | A | Inhibition of human recombinant CYP2C19 at 10 uM using 3-cyano-7-ethoxycoumarin as substrate preincubated for 5 mins followed by enzyme/substrate mix addition measured by fluoroscence plate reader assay | Homo sapiens | 1 | ALA5154888 | single protein format | Scientific Literature | |
| 10. | ALA5166016 | A | Inhibition of human recombinant CYP2C9 at 10 uM using 7-methoxy-4-(trifluoromethyl)coumarin as substrate preincubated for 5 mins followed by enzyme/substrate mix addition measured by fluoroscence plate reader assay | Homo sapiens | 1 | ALA5154888 | single protein format | Scientific Literature | |
| 11. | ALA5166017 | A | Inhibition of human recombinant CYP2D6 at 10 uM using [2-(N,N-diethyl-N-methylammonium)ethy1]-7-methoxy-4-methylcoumarin as substrate preincubated for 5 mins followed by enzyme/substrate mix addition measured by fluoroscence plate reader assay | Homo sapiens | 1 | ALA5154888 | single protein format | Scientific Literature | |
| 12. | ALA5166018 | A | Inhibition of human recombinant CYP3A4 at 10 uM using 7-benzyloxytrifluoromethyl coumarin as substrate preincubated for 5 mins followed by enzyme/substrate mix addition measured by fluoroscence plate reader assay | Homo sapiens | 1 | ALA5154888 | single protein format | Scientific Literature | |
| 13. | ALA5166019 | A | Inhibition of human recombinant CYP3A4 at 10 uM using dibenzylfluorescein as substrate preincubated for 5 mins followed by enzyme/substrate mix addition measured by fluoroscence plate reader assay | Homo sapiens | 1 | ALA5154888 | single protein format | Scientific Literature | |
| 14. | ALA5166020 | T | Inhibition of hERG potassium channel transfected in CHO cells at 10 uM incubated for 30 mins by fluorescence based assay | Homo sapiens | 1 | ALA5154888 | cell-based format | Scientific Literature | |
| 15. | ALA5166021 | A | Apparent permeability in human Caco-2 cells apical to basolateral side incubated for 2 hrs by UPLC-MS/MS analysis | Homo sapiens | 1 | ALA5154888 | cell-based format | Scientific Literature | |
| 16. | ALA5166022 | A | Apparent permeability in human Caco-2 cells basolateral to apical side incubated for 2 hrs by UPLC-MS/MS analysis | Homo sapiens | 1 | ALA5154888 | cell-based format | Scientific Literature | |
| 17. | ALA5166023 | A | Efflux ratio of apparent permeability basolateral to apical side over apical to basolateral side in human Caco-2 cells | Homo sapiens | 1 | ALA5154888 | cell-based format | Scientific Literature | |
| 18. | ALA5166024 | A | Permeability of the compound by PAMPA-BBB assay | 15 | ALA5154888 | assay format | Scientific Literature | ||
| 19. | ALA5166025 | T | Cytotoxicity against mouse Neuro2a cells at 100 uM incubated for 24 hrs by MTT assay | Mus musculus | 1 | ALA5154888 | cell-based format | Scientific Literature | |
| 20. | ALA5166026 | F | Effect on locomotory activity in transgenic Caenorhabditis elegans CL2006 model of paralysis assessed as reduction in defective locomotion by measuring motor index at 0.1 to 10 uM by motor behaviour assay | Caenorhabditis elegans | 2 | ALA5154888 | organism-based format | Scientific Literature |
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