# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5138299 | F | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 34 | ALA5136996 | cell-based format | Scientific Literature | |
2. | ALA5138300 | F | Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 34 | ALA5136996 | cell-based format | Scientific Literature | |
3. | ALA5138301 | T | Cytotoxicity against rat Primary hepatocytes assessed as cell viability at 25 uM incubated for 12 hrs | Rattus norvegicus | 2 | ALA5136996 | cell-based format | Scientific Literature | |
4. | ALA5138302 | F | Induction of cell cycle arrest in human A549 cells assessed as accumulation of cells at G2/M phase incubated for 48 hrs by PI staining based flow cytometry (Rvb = 9.7 to 17.2%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
5. | ALA5138303 | F | Induction of apoptosis in human A549 cells assessed as viable cells at 3 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 91.5 to 92.9%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
6. | ALA5138304 | F | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 3 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 2.07 to 3.24%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
7. | ALA5138305 | F | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 3 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 1.58 to 2.23%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
8. | ALA5138306 | F | Induction of apoptosis in human A549 cells assessed as necrotic cells at 3 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 2.23 to 4.25%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
9. | ALA5138307 | F | Induction of apoptosis in human A549 cells assessed as viable cells at 10 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 91.5 to 92.9%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
10. | ALA5138308 | F | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 10 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 2.07 to 3.24%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
11. | ALA5138309 | F | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 10 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 1.58 to 2.23%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
12. | ALA5138310 | F | Induction of apoptosis in human A549 cells assessed as necrotic cells at 10 uM incubated for 48 hrs by AnnexinV-FITC/PI staining based flow cytometry (Rvb = 2.23 to 4.25%) | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
13. | ALA5138311 | F | Induction of apoptosis in human A549 cells assessed as increase in cleaved caspase-3 expression level at 3 to 10 uM incubated for 48 hrs by western blot analysis | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
14. | ALA5138312 | F | Induction of apoptosis in human A549 cells assessed as increase in cleaved caspase-9 expression level at 3 to 10 uM incubated for 48 hrs by western blot analysis | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
15. | ALA5138313 | F | Induction of apoptosis in human A549 cells assessed as increase in cleaved caspase-8 expression level at 3 to 10 uM incubated for 48 hrs by western blot analysis | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
16. | ALA5138314 | F | Induction of intracellular ROS generation in human A549 cells incubated for 48 hrs by H2DCF-DA staining based flow cytometry | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
17. | ALA5138315 | F | Induction of apoptosis in human A549 cells assessed as decrease in mitochondrial membrane potential by measuring reduction in ratio of red to green fluorescence intensity at 3 to 10 uM incubated for 48 hrs by JC-1 staining based flow cytometry | Homo sapiens | 2 | ALA5136996 | cell-based format | Scientific Literature | |
18. | ALA5138316 | F | Potency index, ratio of scaberol-C IC50 to test compound IC50 for cytotoxicity against human A549 cells by MTT assay | Homo sapiens | 23 | ALA5136996 | cell-based format | Scientific Literature | |
19. | ALA5138317 | F | Potency index, ratio of scaberol-C IC50 to test compound IC50 for cytotoxicity against human NCI-H460 cells by MTT assay | Homo sapiens | 23 | ALA5136996 | cell-based format | Scientific Literature |