# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5142291 | B | Inhibition of human recombinant renin (67 to 406 residues) expressed in HEK293 cells using Nma-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-Dnp as fluorescent quenching substrate incubated for 1 hr by FRET analysis | Homo sapiens | 16 | ALA5137087 | cell-based format | Scientific Literature | |
2. | ALA5142292 | B | Displacement of 125I-labeled angiotensin I from from human plasma renin by gamma counter based competitive radioimmunoassay | Homo sapiens | 10 | ALA5137087 | cell-free format | Scientific Literature | |
3. | ALA5142293 | A | Metabolic stability in human microsomes assessed as intrinsic clearance | Homo sapiens | 13 | ALA5137087 | microsome format | Scientific Literature | |
4. | ALA5142294 | A | Time dependent inhibition of CYP3A4 (unknown origin) assessed as observed inhibition constant | Homo sapiens | 12 | ALA5137087 | single protein format | Scientific Literature | |
5. | ALA5149787 | B | Inhibition of human recombinant renin using Nma-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-Dnp substrate incubated for 1 hr by FRET | Homo sapiens | 23 | ALA5143745 | single protein format | Scientific Literature | |
6. | ALA5149788 | B | Inhibition of renin activity in human plasma by competitive radio immunoassay | Homo sapiens | 16 | ALA5143745 | cell-free format | Scientific Literature | |
7. | ALA5149789 | F | Antihypertensive activity in double transgenic THM mouse carrying both human angiotensinogen and the human renin gene at 10 mg/kg, po measured after 2 to 6 hrs post dose by tail cuff method | Mus musculus | 1 | ALA5143745 | organism-based format | Scientific Literature | |
8. | ALA5149790 | A | Intrinsic clearance in human microsomes | Homo sapiens | 1 | ALA5143745 | microsome format | Scientific Literature | |
9. | ALA5149791 | A | Time dependent inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA5143745 | single protein format | Scientific Literature |