| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149119 | F | Cytotoxicity against human U87 cells assessed as reduction in cell viability at 400 uM measured after 48 hrs in absence of human neutrophil elastase by PrestoBlue reagent based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA5149120 | F | Cytotoxicity against human U87 cells assessed as reduction in cell viability measured after 24 to 72 hrs in presence of human neutrophil elastase by PrestoBlue reagent based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA5149121 | F | Cytotoxicity against human U87 cells assessed as reduction in cell viability at 50 to 250 uM measured after 48 hrs in presence of human neutrophil elastase and eglin C by PrestoBlue reagent based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA5149122 | F | Cytotoxicity against human U87 cells assessed as reduction in cell viability at 50 to 250 uM preincubated with human neutrophil elastase for 24 hrs followed by cell addition and measured after 48 hrs by PrestoBlue reagent based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5149123 | F | Cytotoxicity against human U87 cells assessed as reduction in cell viability at 50 to 250 uM incubated for 48 hrs in presence of human neutrophil elastase/troxerutine by PrestoBlue reagent based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5149124 | F | Induction of apoptosis in human U87 cells assessed as reduction in cell viability at 75 uM measured after 48 hrs by real time-glo Annexin V assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5149125 | F | Induction of apoptosis in human U87 cells assessed as reduction in cell viability at 150 uM measured after 48 hrs by real time-glo Annexin V assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5149126 | F | Induction of apoptosis in human U87 cells assessed as reduction in cell viability at 250 uM measured after 48 hrs by real time-glo Annexin V assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5149127 | F | Induction of apoptosis in human U87 cells assessed as activation of caspase3/7 at 75 to 250 uM measured after 48 hrs in presence of human neutrophil elastase by luminescence based multimode microplate reader assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5149128 | F | Induction of apoptosis in human U87 cells assessed as phosphatidylserine translocation at 75 to 250 uM measured after 48 hrs in presence of human neutrophil elastase | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5149129 | F | Induction of apoptosis in human U87 cells assessed as reduction in cell membrane integrity at 75 to 250 uM measured after 48 hrs in presence of human neutrophil elastase | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5149130 | F | Cytotoxicity against human U87 cells assessed as cell viability at 100 to 400 uM measured after 24 to 72 hrs in absence of human neutrophil elastase by PrestoBlue reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5149131 | F | Induction of apoptosis in human U87 cells assessed as activation of caspase3/7 at 75 to 250 uM measured after 1 to 48 hrs in absence of human neutrophil elastase by luminescence based multimode microplate reader assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5149132 | F | Induction of apoptosis in human U87 cells assessed as phosphatidylserine translocation at 75 to 250 uM measured after 1 to 48 hrs in presence of human neutrophil elastase | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5149133 | F | Induction of apoptosis in human U87 cells assessed as reduction in cell membrane integrity at 75 to 250 uM measured after 1 to 48 hrs in presence of human neutrophil elastase | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5149134 | A | Prodrug activation assessed as human neutrophil elastase mediated TEMPO release by EPR spectometric analysis | 2 | assay format | Scientific Literature | |||
| 17. | ALA5149136 | A | Prodrug activation assessed as TEMPO release after 16 hrs in absence of human neutrophil elastase by EPR spectometric analysis | 2 | assay format | Scientific Literature | |||
| 18. | ALA5149137 | A | Prodrug activation assessed as chymotrypsin mediated TEMPO release | 1 | assay format | Scientific Literature | |||
| 19. | ALA5149138 | A | Prodrug activation assessed as trypsin mediated TEMPO release | 1 | assay format | Scientific Literature | |||
| 20. | ALA5149139 | A | Prodrug activation assessed as urokinase mediated TEMPO release | 1 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!