# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5160032 | F | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth by SYBR Green-I dye based fluorescence analysis | Plasmodium falciparum | 59 | ALA5154768 | organism-based format | Scientific Literature | |
2. | ALA5160033 | T | Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 90 mins by luminescence based analysis | Homo sapiens | 20 | ALA5154768 | assay format | Scientific Literature | |
3. | ALA5160034 | P | Dissociation constant, pKa of the compound | 20 | ALA5154768 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5160035 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA5154768 | cell-based format | Scientific Literature | |
5. | ALA5160036 | A | Chemical stability of the compound in FaSSIF assessed as compound degradation at 37 degreeC measured after 72 hrs | 2 | ALA5154768 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA5160037 | A | Clearance in human liver microsomes | Homo sapiens | 2 | ALA5154768 | microsome format | Scientific Literature | |
7. | ALA5160038 | A | Clearance in rat liver microsomes | Rattus norvegicus | 2 | ALA5154768 | microsome format | Scientific Literature | |
8. | ALA5160039 | A | Clearance in mouse liver microsomes | Mus musculus | 2 | ALA5154768 | microsome format | Scientific Literature | |
9. | ALA5160040 | T | Inhibition of hERG by Qpatch-clamp method | Homo sapiens | 19 | ALA5154768 | assay format | Scientific Literature | |
10. | ALA5160041 | T | Binding affinity to human CDK7 | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature | |
11. | ALA5160042 | T | Binding affinity to human FLT3 | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature | |
12. | ALA5160043 | T | Binding affinity to human KIT | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature | |
13. | ALA5160044 | T | Binding affinity to human PIM1 | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature | |
14. | ALA5160045 | T | Binding affinity to human PIM2 | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature | |
15. | ALA5160046 | T | Binding affinity to human PIM3 | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature | |
16. | ALA5160047 | P | Lipophilicity, log D of compound at pH 7.4 | 26 | ALA5154768 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA5160058 | T | Binding affinity to human HASPIN | Homo sapiens | 2 | ALA5154768 | assay format | Scientific Literature |