# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5134957 | F | Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
2. | ALA5134958 | F | Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
3. | ALA5134959 | F | Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
4. | ALA5134960 | F | Antiproliferative activity against human K562 cells | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
5. | ALA5134961 | B | Inhibition of FLT3 ITD mutant (unknown origin) | Homo sapiens | 11 | ALA5131485 | single protein format | Scientific Literature | |
6. | ALA5134962 | B | Inhibition of PDGFRalpha (unknown origin) | Homo sapiens | 11 | ALA5131485 | single protein format | Scientific Literature | |
7. | ALA5134963 | B | Inhibition of CDK2 (unknown origin) | Homo sapiens | 11 | ALA5131485 | single protein format | Scientific Literature | |
8. | ALA5134964 | B | Inhibition of FLT3 ITD mutant in human MV4-11 cells assessed as reduction in autophosphorylation at Y589/591 residue at 5 to 25 nM measured after 1 hr by immunoblotting analysis | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
9. | ALA5134965 | B | Inhibition of FLT3 ITD mutant in human MV4-11 cells assessed as reduction in STAT3 phosphorylation at Y694 residue at 5 to 25 nM measured after 1 hr by immunoblotting analysis | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
10. | ALA5134966 | B | Inhibition of FLT3 ITD mutant in human MV4-11 cells assessed as reduction in ERK1/2 phosphorylation at T202/Y204 residue at 5 to 25 nM measured after 1 hr by immunoblotting analysis | Homo sapiens | 11 | ALA5131485 | cell-based format | Scientific Literature | |
11. | ALA5134979 | F | Cell cycle arrest in human MV4-11 cells expressing FLT3-ITD mutant assessed as increase in accumulation at G1 phase at 1 to 125 nM measured after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 6 | ALA5131485 | cell-based format | Scientific Literature |