# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5146032 | B | Inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
2. | ALA5146033 | B | Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric assay | Mus musculus | 12 | single protein format | Scientific Literature | ||
3. | ALA5146034 | B | Selectivity index, ratio of IC50 for inhibition of mose CD73 to IC50 for inhibition of human CD73 | 3 | assay format | Scientific Literature | |||
4. | ALA5146036 | B | Potency index, ratio of betulinic acid IC50 to test compound IC50 for inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
5. | ALA5146037 | F | Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
6. | ALA5146038 | F | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature |