| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5166040 | B | Inhibition of human PPIP5K2 in HCT-116 cells assessed as effect on InsP5 level at 2 uM measured after 3 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5166041 | F | Anti-diabetic activity in 16 hrs fasted C57BL6J mouse model of high fat diet-induced obesity assessed as reduction in pyruvate-induced gluconeogenesis at 2 mg/kg, ip administered for 4 weeks by pyruvate tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5166043 | B | Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA5166044 | B | Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured after 60 to 120 mins by malachite green based colorimetric - DIPP1 coupled enzyme assay | Homo sapiens | 37 | assay format | Scientific Literature | ||
| 5. | ALA5166045 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP6K2 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured after 60 to 120 mins by malachite green based colorimetric - DIPP1 coupled enzyme assay | Homo sapiens | 37 | assay format | Scientific Literature | ||
| 6. | ALA5166046 | B | Inhibition of N-terminal 6His-sumo-tagged recombinant human IP6K3 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured after 60 to 120 mins by malachite green based colorimetric - DIPP1 coupled enzyme assay | Homo sapiens | 37 | assay format | Scientific Literature | ||
| 7. | ALA5166047 | B | Selectivity ratio of IC50 for N-terminal 6His-sumo-tagged recombinant human IP6K3 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured to IC50 for N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP | Homo sapiens | 36 | assay format | Scientific Literature | ||
| 8. | ALA5166051 | B | Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation at 10 nM measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA5166052 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP6K2 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation at 10 nM measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA5166053 | B | Inhibition of N-terminal 6His-sumo-tagged recombinant human IP6K3 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation at 10 nM measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA5166054 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP6K2 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA5166055 | B | Inhibition of N-terminal 6His-sumo-tagged recombinant human IP6K3 expressed in Escherichia coli assessed as inhibition of [3H]-InsP6 phosphorylation measured after 180 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA5166056 | B | Binding affinity to MBP-tagged recombinant human IP6K2 at 400 uM by isothermal titration calorimetry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA5166057 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IP3KA (173 to 461 residues) expressed in Escherichia coli using [3H]-Ins91,4,5)P3 as substrate measured after 60 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA5166058 | B | Inhibition of N-terminal 6His-tagged/TEV cleavage site fused recombinant human IPMK expressed in Escherichia coli using [3H]-Ins(1,4,5)P3 as substrate measured after 60 mins by HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA5166059 | B | Inhibition of human IP3KA in HCT-116 cells assessed as effect on InsP5 level at 2 uM measured after 3 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5166060 | B | Inhibition of human IP3KA in HCT-116 cells assessed as effect on InsP6 level at 2 uM measured after 3 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5166061 | B | Inhibition of human IPMK in HCT-116 cells assessed as effect on InsP5 level at 2 uM measured after 3 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5166062 | B | Inhibition of human IPMK in HCT-116 cells assessed as effect on InsP6 level at 2 uM measured after 3 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5166063 | B | Inhibition of human PPIP5K2 in HCT-116 cells assessed as effect on InsP6 level at 2 uM measured after 3 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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