| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5100431 | B | Positive allosteric modulator activity in human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as decrease in radioligand [125I]I-AB-MECA dissociation from A3AR receptor by measuring remaining radioligand-bound receptor at 10 uM preincubated for 2 hrs followed by AR agonist NECA addition and measured after 1 hr by radioligand competition binding assay relative to control (Rvb= 26%) | Homo sapiens | 27 | cell membrane format | Scientific Literature | ||
| 2. | ALA5100433 | B | Positive allosteric modulator activity in wild type human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as increase in CI-IB-MECA induced [35S]GTPGAgammaS binding to receptor at 1 uM preincubated for 1 hrs with CI-IB-MECA further incubated with [35S]GTPGAgammaS for 2 hrs in presence of PSB-603,ZM241385 and ADP to degrade endogenous AR by liquid scintillation spectrometry | Homo sapiens | 32 | cell membrane format | Scientific Literature | ||
| 3. | ALA5100437 | B | Displacement of [3H]-LSD from human sigma1 receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay | Homo sapiens | 6 | cell membrane format | Scientific Literature | ||
| 4. | ALA5100438 | B | Displacement of [3H]-DTG from human sigma2 receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay | Homo sapiens | 9 | cell membrane format | Scientific Literature | ||
| 5. | ALA5100444 | A | Stability of the compound in simulated intestinal fluid at pH 6 to 8 assessed as compound remaining at 120 mins by LC-MS/MS analysis | 3 | assay format | Scientific Literature | |||
| 6. | ALA5100445 | A | Stability of the compound in simulated intestinal fluid at pH 6 to 8 assessed as half life at 120 mins by LC-MS/MS analysis | 3 | assay format | Scientific Literature | |||
| 7. | ALA5100446 | A | Stability of the compound in simulated gastric fluid at pH 1 to 2 assessed as compound remaining at 120 mins by LC-MS/MS analysis | 3 | assay format | Scientific Literature | |||
| 8. | ALA5100447 | A | Stability of the compound in simulated gastric fluid at pH 1 to 2 assessed as half life at 120 mins by LC-MS/MS analysis | 3 | assay format | Scientific Literature | |||
| 9. | ALA5100448 | A | Stability in human plasma assessed as compound remaining and measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 10. | ALA5100449 | A | Stability in rat plasma assessed as compound remaining and measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 11. | ALA5100450 | A | Stability in mouse plasma assessed as compound remaining and measured after 120 mins by LC-MS/MS analysis | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 12. | ALA5100451 | A | Stability in human plasma assessed as half life and measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 13. | ALA5100452 | A | Stability in rat plasma assessed as half life and measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 14. | ALA5100453 | A | Stability in mouse plasma assessed as half life and measured after 120 mins by LC-MS/MS analysis | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 15. | ALA5100454 | A | Inhibition of CYP1A2 in human liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 16. | ALA5100455 | A | Inhibition of CYP2C9 in human liver Microsome using diclofenac as substrate in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 17. | ALA5100456 | A | Inhibition of CYP2C19 in human liver Microsome using omeprazole as substrate in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 18. | ALA5100457 | A | Inhibition of CYP2D6 in human liver Microsome using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 19. | ALA5100458 | A | Inhibition of CYP3A4 in human liver Microsome using midazolam as substrate in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 20. | ALA5100459 | A | Inhibition of CYP1A2 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 3 | microsome format | Scientific Literature |
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