# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5153031 | B | Inhibition of wild type EGFR (unknown origin) assessed as percent of control activity at 1 uM by radiometric protein kinase-reaction biology assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
2. | ALA5153032 | B | Inhibition of EGFR (unknown origin) Del19 mutant assessed as percent of control activity at 1 uM by radiometric protein kinase-reaction biology assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
3. | ALA5153033 | B | Inhibition of EGFR (unknown origin) d747-752/P7535 mutant assessed as percent of control activity at 1 uM by radiometric protein kinase-reaction biology assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
4. | ALA5153034 | B | Inhibition of wild type EGFR (unknown origin) preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
5. | ALA5153035 | B | Inhibition of EGFR (unknown origin) Del19 mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
6. | ALA5153036 | B | Inhibition of EGFR (unknown origin) L858R mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
7. | ALA5153037 | B | Inhibition of EGFR (unknown origin) L858R/T790M mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay | Homo sapiens | 27 | ALA5150044 | single protein format | Scientific Literature | |
8. | ALA5153056 | F | Antiproliferative activity against mouse BaF3 cells expressing L858R assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay | Mus musculus | 9 | ALA5150044 | cell-based format | Scientific Literature | |
9. | ALA5153060 | F | Antiproliferative activity against mouse BaF3 cells expressing Del19 assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay | Mus musculus | 9 | ALA5150044 | cell-based format | Scientific Literature | |
10. | ALA5153061 | F | Antiproliferative activity against mouse BaF3 cells expressing De119/C797S assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay | Mus musculus | 9 | ALA5150044 | cell-based format | Scientific Literature | |
11. | ALA5153067 | B | Inhibition of EGFR T790M mutant in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 2 | ALA5150044 | cell-based format | Scientific Literature | |
12. | ALA5153068 | B | Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 2 | ALA5150044 | cell-based format | Scientific Literature | |
13. | ALA5153069 | B | Inhibition of EGFR L858R mutant in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 5 | ALA5150044 | cell-based format | Scientific Literature | |
14. | ALA5153070 | B | Inhibition of EGFR Del19 mutant in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 2 | ALA5150044 | cell-based format | Scientific Literature | |
15. | ALA5153071 | B | Inhibition of EGFR De119/C797S mutant in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 2 | ALA5150044 | cell-based format | Scientific Literature | |
16. | ALA5153072 | B | Inhibition of EGFR C979S double mutant in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 2 | ALA5150044 | cell-based format | Scientific Literature | |
17. | ALA5153073 | B | Inhibition of ERK1/2 phosphorylation in mouse BaF3 cells harboring L858R mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 4 | ALA5150044 | cell-based format | Scientific Literature | |
18. | ALA5153074 | B | Inhibition of ERK1/2 phosphorylation in mouse BaF3 cells harboring Del19 mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 4 | ALA5150044 | cell-based format | Scientific Literature | |
19. | ALA5153075 | B | Inhibition of ERK1/2 phosphorylation in mouse BaF3 cells harboring De119/C797S mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 4 | ALA5150044 | cell-based format | Scientific Literature | |
20. | ALA5153076 | B | Inhibition of ERK1/2 phosphorylation in mouse BaF3 cells harboring L858R/C797S double mutant assessed as ERK1/2 phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis | Mus musculus | 4 | ALA5150044 | cell-based format | Scientific Literature |