# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5105160 | B | Inhibition of His-tagged Mycobacterium tuberculosis H37Rv InhA expressed in Escherichia coli BL21 using 2-trans-dodecenoyl-CoA as substrate incubated for 30 mins in presence of NADH by fluorescence based assay | Mycobacterium tuberculosis | 2 | assay format | Scientific Literature | ||
2. | ALA5105161 | F | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA5105162 | F | Antibacterial activity against Mycobacterium tuberculosis H37Rv ATCC 25618 assessed as bacterial growth inhibition incubated for 5 days by fluorescence based assay | Mycobacterium tuberculosis | 2 | organism-based format | Scientific Literature | ||
4. | ALA5105163 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA5105164 | A | Protein binding in human serum | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
6. | ALA5105165 | A | Protein binding in mouse plasma | Mus musculus | 1 | cell-free format | Scientific Literature | ||
7. | ALA5139585 | F | Antibacterial activity against Mycobacterium tuberculosis Erdman (TMCC 107) assessed as reduction in resistance generation frequency | Mycobacterium tuberculosis | 1 | organism-based format | Scientific Literature | ||
8. | ALA5139604 | F | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth incubated for 5 days | Mycobacterium tuberculosis | 2 | organism-based format | Scientific Literature | ||
9. | ALA5139605 | F | Antibacterial activity against Mycobacterium tuberculosis Erdman in acute Mtb infection C57BL/6-IFN-gamma-tm1Ts KO mouse model assessed as reduction in log10 CFU in lungs at 50 mg/kg, po qd for 9 consecutive days | Mycobacterium tuberculosis | 1 | organism-based format | Scientific Literature | ||
10. | ALA5139608 | B | Inhibition of His-tagged Mycobacterium tuberculosis H37Rv InhA expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence based assay | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
11. | ALA5139609 | F | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability treated for 72 hrs by Cell Titer Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA5139610 | A | Half life in CD-1 mouse at 5 mg/kg, iv measured for 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
13. | ALA5139611 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg measured for 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
14. | ALA5139612 | F | Antibacterial activity against Mycobacterium tuberculosis Erdman (TMCC 107) in chronic Mtb infection BALB/c mouse model assessed as reduction in log10 CFU in lungs at 100 mg/kg, po via gavage upto 8 weeks | Mycobacterium tuberculosis | 1 | organism-based format | Scientific Literature | ||
15. | ALA5139613 | F | Antibacterial activity against Mycobacterium tuberculosis Erdman (TMCC 107) in Mtb infection C3HeB/FeJ mouse model assessed as reduction in log10 CFU in lungs at 100 mg/kg, po via gavage upto 4 weeks | Mycobacterium tuberculosis | 1 | organism-based format | Scientific Literature | ||
16. | ALA5139614 | F | Antibacterial activity against Mycobacterium tuberculosis Erdman (TMCC 107) in Mtb infection C3HeB/FeJ mouse model assessed as reduction in resistance generation frequency administered for 8 weeks relative to control | Mycobacterium tuberculosis | 2 | organism-based format | Scientific Literature | ||
17. | ALA5139618 | F | Antibacterial activity against extensively drug-resistant Mycobacterium tuberculosis clinical isolate assessed as inhibition of bacterial growth in presence of SMARt-420 | Mycobacterium tuberculosis | 1 | organism-based format | Scientific Literature | ||
18. | ALA5139619 | F | Antibacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate assessed as inhibition of bacterial growth in presence of SMARt-420 | Mycobacterium tuberculosis | 1 | organism-based format | Scientific Literature |